Medline Repository

Benzoate --> Sodium

PMID
Sentence
Species
5920513 The mechanism of solubilization of water insoluble substances with sodium benzoate derivatives. I. The interaction between water insoluble substances and sodium benzoate derivatives in aqueous solution. Unknown
5920514 The mechanism of solubilization of water insoluble substances with sodium benzoate derivatives. II. Solubilities of water insoluble substances in aqueous sodium benzoates solutions. Unknown
5920515 The mechanism of solubilization of water insoluble substances with sodium benzoate derivatives. 3. Decrease of activity coefficient of water insoluble substances by addition of sodium benzoate derivatives in aqueous systems. Unknown
6059441 Deaggregation behavior of a relatively insoluble substituted benzoic acid and its sodium salt. Unknown
5787677 Determination of a gustatory L70 point for sodium benzoate. Human
5352763 The use of sodium 11C-benzoate in renal visualization. Dogs
5379020 The mechanism of solubilization of khellin by sodium benzoate and salicylate. Unknown
5441599 Combined effects of some local anesthetics with sodium benzoate. Rabbits
939740 Recoveries are 95% for sodium sulfite, 103% for sodium benzoate, 90% for potassium sorbate, and 81% expected recovery for sodium ascorbate. unknown
951427 Diethyl ether anesthesia, sodium hexobarbital (20 mg/kg), diphenylhydantoin (50 mg/kg), strychnine (1 mg/kg) and picrotoxin (1-0.25 mg/kg) effectively induced the copulatory response (lordotic behavior) in estradiol benzoate treated ovariectomized rats although no progesterone was given. Rats
939740 Recoveries are 95% for sodium sulfite, 103% for sodium benzoate, 90% for potassium sorbate, and 81% expected recovery for sodium ascorbate. unknown
951427 Diethyl ether anesthesia, sodium hexobarbital (20 mg/kg), diphenylhydantoin (50 mg/kg), strychnine (1 mg/kg) and picrotoxin (1-0.25 mg/kg) effectively induced the copulatory response (lordotic behavior) in estradiol benzoate treated ovariectomized rats although no progesterone was given. Rats
1010041 The synthesis of 6-nitro and 6-amino-derivatives (III g,h) have been respectively accomplished by hydrolysis and hydrogenolysis of 6-nitro-2-benzylidenaminoisoindolin-1-one (IV g), prepared by chlorination and ring closure with sodium carbonate of benzylidenhydrazide of 5-nitro-2-hydroxymethyl-benzoic acid (Scheme 2). unknown
1026518 Caffeine sodium benzoate was injected intraperitoneally at one time in doses of 1 and 50 mg/100 g to rates aged 30 days and 3--5 months. Rats
833108 Sodium benzoate is used as an internal standard. Unknown
850482 Cerebrospinal fluid glycine in nonketotic hyperglycinemic: effect of treatment with sodium benzoate and a ventricular shunt. Human
850482 Oral sodium benzoate lowered cerebrospinal fluid (CSF) glycine by greater than 40%, but did not change the abnormal plasma: CSF ratio. unknown
850482 Treatment of one patient with sodium benzoate from birth did not prevent mental retardation; the degree of brain stem depression was a function of CSF glycine in another patient. unknown
857020 Similarly, sodium benzoate and 1-chloropropan-2-one produced 1-benzoyloxypropan-2-one. unknown
909059 Effect of ortho-iodo sodium benzoate on hemoglobin-oxygen affinity in normal and ischemic myocardium. Dogs
909059 The effect of ortho-iodo sodium benzoate (OISB) on the oxyhemoglobin dissociation curve of coronary venous blood was studied in an isolated canine heart preparation perfused at a constant coronary blood flow. unknown
917011 It was not inhibited by PMSF, nor by two trypsin and chymotrypsin-like protease inhibitors, nor by iodoacetamide, but was inhibited by sodium bisulfite and para-hydroxymercury benzoate (PHMB). Rats
758448 The method not only separates potassium guaiacolsulfonate from phenylephrine hydrochloride but also from some other ingredients: chlorpheniramine maleate, sodium benzoate, colors, and flavors. Unknown
500543 Gas-liquid chromatographic determination of sorbic acid and sodium benzoate in table sirup. Unknown
500543 A gas-liquid chromatographic method is described for the simultaneous determination of sorbic acid and sodium benzoate in table sirup. unknown
500543 Coefficients of variation for sorbic acid and sodium benzoate are 0.62 and 0.41%, respectively. unknown
580002 Pretreatment of caffeine prior to injection by a) addition of sodium salicylate or sodium benzoate, b) increase in temperature or c) preliminary dissolution in hydrochloric acid, did not change the cardiovascular effects when injected i.v. at equivalent doses in urethane-anaesthetized rats. Rats
582962 Both in normal and experimentally jaundiced rats cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) induces a greater and longer lasting increase in bile flow and a greater increase in bilirubin and glucuronic acid secretion than do the choleretics sodium 2-(2-hydroxy-3n hexoxy-propoxy)-benzoate and dehydrocholic acid. Rats
327934 Both sodium benzoate and calcium propionate caused the synthesis of unusual fatty acids. unknown
411562 Aflatoxin production by a toxigenic strain of Aspergillus flavus was greatly reduced by benzoic acid and sodium benzoate in synthetic media. Aspergillus flavus
411562 Benzoic acid, sodium benzoate, or autoclaving the cell-free extract appear to have respectively blocked or denatured an enzymatic step late in the biosynthetic pathway of aflatoxin B1. unknown
402738 By use of different activators and inhibitors, TOCP(tri-o-cresyl phosphate), PCMB (parachloromercury benzoate), NiCl2, Pb(NO3)2, HgCl2, Hg(NO3)2, eserine and sodium taurocholate, it is shown that the esterase in the cyst cells and in group I cells of the guinea pig thyroid probably are A-esterase isoenzymes. Guinea Pigs
183220 On the other hand, the effect of sodium benzoate and sodium salicylate varied with concentration. unknown
18366 The application of caffeine sodium benzoate, camphor, metrasol, lobeline hydrochloride and cytisine, employed in different doses, proved to be little effective. unknown
19682 The effects of sodium chloride, sodium acetate, benzoic acid, sodium benzoate, malonic acid, and sodium malonate on growth and aflatoxin production by Aspergillus flavus were investigated in synthetic media. Aspergillus flavus
19682 Benzoic acid (pH 3.9) and sodium benzoate (pH 5.0) at 0.4 g/100 ml completely inhibited growth and aflatoxin production. unknown
19682 The inhibitory action of benzoic acid and sodium benzoate appeared to be a function of undissociated benzoic acid molecules. unknown
14943 A new and simple colorimetric method for human serum lipase [EC 3.1.1.3] assay has been developed, using 2,3-dimercaptopropan-1-ol tributyroate as a substrate, 5,5'-dithiobis(2-nitro-benzoic acid) as a chromogenic reagent, phenylmethylsulfonyl fluoride as an inhibitor of serum esterases, and sodium dodecylsulfate as a lipase activator. Human
16690 The enzyme activity was inhibited by parachloromercuric benzoate, isonicotinic acid hydrazide, mercuric chloride, and sodium borate. unknown
18008 Guaifenesin, methylparaben and sodium benzoate interfere only with pheniramine maleate. unknown
36146 The effects of pH and of several passive anion transport inhibitors such as dinitrofluorobenzene, sodium salicylate, sodium benzoate and phenylbutazone suggest that urate and chloride are transported by different mechanisms. unknown
37325 The common liquid dosage preservatives methylparaben, propylparaben, and sodium benzoate do not interfere with quantitative prednisolone, prednisone, and hydrocortisone determinations. unknown
84067 In some instances the various electrophysiological tests were preceeded by the administration of Tensilon, calcium gluconate and sodium benzoate caffeine. Human
1129280 The effect of sodium benzoate and taurocholic acid feeding on human bile composition. Human
1129280 Four patients were fed sodium benzoate after stabilization following common bile duct exploration. unknown
1035401 4 hydroxybenzoic acid and sodium acid and sodium benzoate were the more common inducers in the latter patients. Human
1035401 Tartrazine, 4 hydroxybenzoic acid, sodium benzoate, tiramin and penicilin are included in the test. unknown
876270 Compounds such as N-alkyl-N'-nitroguanidines, barbital, sodium benzoate, saccharin sodium, sodium nitrite, sodium nitrate and 4-aminoquinoline-1-oxide were positive in our chromosome tests, but they have not been conclusively tested for their carcinogenicity. Hamsters
412611 Fourteen of these were given provocation tests by drinking, on separate occasions of sulphur dioxide, sodium benzoate and tartrazine, which are present in all orange drinks. Human
412611 Eight reacted to sulphur dioxide with a fall in FEV1, four to sodium benzoate and one to tartrazine, and four did not react to any of these agents. unknown
788461 The bactericidal action of benzoic acid and sodium acetate on the gram-negative flora of dialysis fluid. Bacteria
Enterobacteriaceae
Human
Klebsiella pneumoniae
Yeasts
864744 Among them, 7 chemicals, including 5 known oncogens (N-n-butyl-N-nitrosourethan, N-methyl-N-nitrosourea, beta-propiolacton, methylazoxymethanol acetate, and propane sultone) and 2 non-oncogens (potassium sorbate and sodium benzoate) were inducers of aberrations and/or SCE, although the effective doses for the last two agents were considerably higher. unknown
7364680 One gram of caffeine (dissolved in 10 ml of saline-sodium benzoate solution) was infused into the pigs through a jugular catheter at a rate of 1.0 ml/min. Swine
7375243 Impressive effects of strychnine treatment initiated in two infants at ages 5 and 6 1/2 months, and given in addition to sodium benzoate and anticonvulsants, have been reported. unknown
7377158 Three full-term infants manifested CNS irritability after the parenteral administration of large doses of caffeine and benzoate sodium injection in the delivery room for respiratory depression. Human
7433507 Hexamine, formamol, sodium salicylate, sodium benzoate, nicotinamide, aminophylline, aminophenazone, phenazone and paracetamol were studied. Unknown
7433507 However, aminophenazone, formamol, phenazone, paracetamol, sodium benzoate, and aminophylline retarded the dissolution rate of the drug. unknown
7441132 Report of carcinogenesis bioassay of sodium benzoate in rats: absence of carcinogenicity of sodium benzoate in rats. Rats
7441132 The carcinogenicity of sodium benzoate was examined in Fischer 344 rats. unknown
7441132 Sodium benzoate was administered in the diet for 18 to 24 months at two dose levels; concentrations of 2% and 1% in the diet, which corresponded to the maximum tolerated dose (MTD) and 1/2 MTD as estimated from the data obtained by 6-week toxicity study. unknown
7441132 It was concluded that no evidence of carcinogenicity in rats from sodium benzoate was demonstrated. unknown
7441417 The relative effectiveness of exchange transfusion, peritoneal dialysis, arginine, and sodium benzoate was evaluated during 44 episodes of hyperammonemic coma in 31 patients with congenital urea cycle enzymopathies. Human
7441417 When sodium benzoate (250 mg/kg/day) was used during eight episodes of coma, six patients responded with a significant decrease in plasma ammonium. unknown
7259152 Sorbic acid at 500 ppm and above inhibited the growth of this yeast while sodium benzoate and potassium metabisulphite were unable to suppress the growth even at 1000 ppm. Candida
7271064 During this incubation there was stimulation of the granulocyte chemiluminescence, which was proportional to the virus dose, prevented by treatment with cytochalasin B, and reduced by catalase and sodium benzoate but not by superoxide dismutase. unknown
7272511 Treatment of normal PMN with a mixture of scavengers specific for H2O2 (catalase, 1600 U/ml), O2-.(superoxide dismutase, 100 micrograms/ml), and for HO., (sodium benzoate, 1mM) during zymosan stimulation gave S values similar to those of resting cells. unknown
7342976 GSH, FeSO4 and luminol was inhibited by catalase, superoxide dismutase, scavengers of hydroxyl radicals (sodium benzoate, n-butanol, D-mannitol, dimethyl sulphoxide) or metal-ion chelators (EDTA, diethylenetriaminepenta-acetic acid, diethyldithiocarbamate. desferroxamine), D-glucose, L-glucose, D-mannose, D-fructose, 3-O-methyl-D-glucose, NAD+, NADH, NADP+ or NADPH, but not by urea or enzymically inactive superoxide dismutase. unknown
7130163 Benzoate-1,2-dioxygenase exhibited two protein bands (alpha and beta) on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and their molecular weights were estimated to the 50,000 and 20,000, respectively. unknown
7140873 Sodium benzoate and other benzoic compounds, as well as tartrazine and other azo dyes, were found to give similar but milder adverse reactions than acetylsalicylic acid. Human
7197984 Solutions of caffeine, caffeine citrate and sodium chloride did not form a precipitate with chlorpromazine but precipitates were formed by sodium salicylate, sodium benzoate and trisodium citrate. Coffee
Human
Rats
6783720 Oestradiol benzoate (2 microgram s.c.) inhibited LH secretion in conscious animals and in those anaesthetized with sodium pentobarbitone, but not in urethane-anaesthetized guinea-pigs. unknown
6846170 Effects of ortho-iodo sodium benzoate on acute myocardial ischemia, hemodynamic function, and infarct size after coronary artery occlusion in dogs. Dogs
6846170 Ortho-iodo sodium benzoate (OISB) decreases the affinity of blood for oxygen, thus enhancing potential tissue oxygen delivery. unknown
6687603 The luminol-dependent chemiluminescence (CL) of neutrophils phagocytosing zymosan is inhibited by superoxide dismutase (SOD), catalase, sodium benzoate, and 2,5-dimethyl furan. Human
6685191 Sodium azide, an 1O2 scavenger and potent inhibitor of peroxidase, and sodium benzoate, an OH. scavenger, both induced 90% reductions of light output from both cell types in resting or stimulated states. unknown
6746472 Aspartame is quantitated in the presence of other beverage additives such as saccharin, caffeine, sodium benzoate, artificial colors, and artificial flavors. unknown
6543907 Serial recordings were made following injections of caffeine sodium benzoate, succinylcholine, and halothane at the test site. Human
6344621 They are, in decreasing order of frequency, as follows: indomethacin (100 percent), ibuprofen, mefenamic acid, phenylbutazone, sodium benzoate, tartrazine and acetaminophen (5 percent). unknown
6435634 Such a breakage was strikingly inhibited by catalase or 50 mM sodium benzoate, but not by superoxide dismutase. unknown
6290410 A strong decrease of the e.p.r. signal was observed in the presence of various OH. scavengers like t-butanol, isopropanol or sodium benzoate. unknown
6300746 Choline and folic acid were added for one-carbon unit transfer and sodium benzoate to bind excessive glycine. unknown
6111891 The free radical scavengers, phenol, thioanisole and sodium benzoate all produced less than 30% inhibition of 12-DOPPA induced erythema and less than 15% inhibition of 12-DOPPAA, whereas aminopyrine produced 70% and 25% inhibition of 12-DOPPA and 12-DOPPAA respectively. unknown
7444162 The inversion can be inhibited by administering D-ethionine simultaneously with either kojic acid or sodium benzoate, both inhibitors of D-amino acid oxidase. Rats
7444162 Sodium benzoate administration is tolerated very well by rats and therefore may be used in chronic experiments. unknown
6980987 When 8 was treated with sodium benzoate in hot DMF and the blocking groups were removed, 9-(5-methyl-2-furyl)adenine (9) and 9-(3-deoxy-alpha-benzoate in hot DMF and the blocking groups were removed, 9-(5-methyl-2-furyl)adenine (9) and 9-(3-deoxy-alpha-L-threo-pentofuranosyl)adenine (10) were the products. unknown
6980987 It was demonstrated that sodium benzoate was solely responsible for formation of the 5-methyl-2-furyl ring and that the first step was formation of the 4',5'-olefin. unknown
6850420 However, the sensitivity of the two kinds of cells to potassium sorbate, sodium benzoate, and sodium propionate was essentially the same, but the 46 degrees C-cells were more resistant to butylated hydroxyanisole and sodium nitrite. Cattle
Legumes
Staphylococcus aureus
7142957 Initial benzoate transport rates are inhibited by CCCP, sodium azide, arsenate and DCCD. Unknown
6889404 Sodium benzoate and arginine: alternative pathway therapy in inborn errors of urea synthesis. Human
6636107 Subsequent treatment, consisting of protein-restriction, exchange transfusions, arginine suppletion and using an alternative pathway for waste nitrogen excretion (through sodium benzoate administration), resulted in a stable clinical and biochemical condition. Human
6640001 Effect of sodium benzoate on the cutaneous bilirubin content of the adult Gunn rat. Rats
6660222 Preparation of caffeine and sodium benzoate injection. Unknown
6670711 Hyperargininemia: clinical course and treatment with sodium benzoate and phenylacetic acid. Human
6670711 In a patient with hyperargininemia, oral administration of sodium benzoate or phenylacetic acid together with an essential amino acid mixture was used to prevent hyperammonemia and to decrease plasma and CSF concentrations of arginine. unknown
6670711 Sodium benzoate reduced the plasma ammonia levels, which was confirmed by the increase of urinary excretion of hippuric acid. unknown
6324535 Effect of sodium benzoate on polymorphonuclear leukocyte function. Human
Staphylococcus aureus
6324535 Sodium benzoate is widely used as a food preservative and reputed to be a scavenger of hydroxyl radical (.OH). unknown
6324535 The effects of sodium benzoate on the function of polymorphonuclear leukocytes (PMN) stimulated by S. aureus or the chemical agent, phorbol myristate acetate (PMA) were examined in vitro using assays of chemiluminescence (CL), total bactericidal activity, intracellular recovery of bacteria, as well as release of lactate dehydrogenase (LDH), lysozyme and superoxide anion (O2(-)). unknown
6324535 Sodium benzoate decreased chemiluminescence, superoxide anion and lysozyme release by PMN stimulated with S. aureus but did not similarly affect these responses of PMN to the chemical agent, PMA. unknown
6324535 The ability of PMN to kill S. aureus was also impaired by sodium benzoate and associated with a reduced number of intracellular bacteria recovered after 90 minutes incubation. unknown
6324535 LDH release from PMN was not demonstrable at concentrations of sodium benzoate below 100 mM indicating that damage can not account for these findings. unknown
6324535 The underlying mechanism of the altered bactericidal function of PMN treated with sodium benzoate appears to be a result of decreased uptake of S. aureus. unknown
6318974 While sodium benzoate was particularly effective in preventing drug-induced DNA damage and cytotoxicity, a number of other scavengers were not. unknown
6693980 Similar experiments with diets supplemented with 1% sodium benzoate to induce alternative pathways for nitrogen excretion were also without effect. unknown
6693980 These results are in contrast to recent clinical studies reporting the effectiveness of sodium benzoate in treating hyperammonemia in patients with urea cycle enzyme defects. unknown
6694094 Sodium benzoate was used as a test drug. Human
6694094 After absorption, sodium benzoate is conjugated with glycine to give hippuric acid which is rapidly eliminated (t 1/2 = 0.5 h). unknown
6694094 The absorption influx of sodium benzoate per unit area (phi in) could be calculated using the steady-state concentration of hippuric acid during rectal perfusion, the separately measured total body clearance after intravenous injection, and a designated absorption surface of the rectum. unknown
6694094 Four volunteers were perfused with four different solutions of sodium benzoate, and it was found that phi in was proportional to the four concentrations used. unknown
6321355 We have shown that the hydroxyl radical scavengers sodium benzoate, phenol, dimethyl sulfoxide, sodium formate, and mannitol protect chicken erythrocyte (Ec) target cells from lysis by K-cells in plaque assays. Chickens
Human
6321355 The protection afforded by benzoate, phenol, mannitol, and dimethyl sulfoxide was abrogated if the target cells were pretreated with sodium chromate. unknown
6700396 The use of 131I-sodium benzoate made it possible to establish disorder of antitoxic hepatic function in 60% of patients with esophageal cancer as well as differences of this function depending on the level of tumor site in the esophagus. Human
6707802 Treatment of hyperargininemia with sodium benzoate and arginine-restricted diet. Human
6325516 Forty-eight Holstein calves were fed one of four liquid diets from 3 to 30 days of age to compare sodium benzoate, propionic acid, and formaldehyde as preservatives for colostrum. unknown
6325516 Diets were 2.73 kg of 1) naturally fermented colostrum, or colostrum treated with 2) sodium benzoate (.5% by weight), 3) propionic acid (1.0% by weight), or 4) formaldehyde (.05% by weight). unknown
6325516 Daily gain from 0 to 4 wk and 0 to 6 wk favored calves fed colostrum treated with sodium benzoate or propionic acid. unknown
6720706 Inadvisability of using caffeine and sodium benzoate in neonates. Human
6428329 In addition to treatment with sodium benzoate and amino acid keto analogues, mannitol may be useful in hyperammonaemia and nocturnal gavage feeding aids maintenance treatment. Human
6745539 Lack of tumorigenicity of sodium benzoate in mice. Mice
6745539 Sodium benzoate was administered as a 2% solution in drinking water for life to randomly bred Swiss mice. unknown
6469906 Liquid chromatographic determination of sodium saccharin, caffeine, aspartame, and sodium benzoate in cola beverages. Unknown
6469906 A rapid method has been developed for the determination of sodium saccharin, caffeine, aspartame, and sodium benzoate in cola beverages. unknown
6592159 Synthesis and purification of sodium [11C]benzoate for physiological and metabolic studies: evaluation in a tumor-bearing dog. Dogs
6238137 Airborne contact urticaria due to sodium benzoate in a pharmaceutical manufacturing plant. Human
6238137 Three workers exposed to airborne contact with sodium benzoate (SB) in a pharmaceutical plant developed transient urticaria related to skin contamination with SB. unknown
6501150 Synthetic dyes, benzoic acid, sorbic acid, and saccharin are extracted simultaneously from soft drinks with 0.01M tri-n-octylamine at pH = 5.5 and are back-extracted to an aqueous phase with 0.1M sodium perchlorate. unknown
6524951 Sodium benzoate was given for three weeks after birth and again from 7 months of age together with sodium phenylacetate to improve protein tolerance. Human
6527278 Determination of the structure of a synthetic impurity in guaifenesin: modification of a high-performance liquid chromatographic method for phenylephrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, and sodium benzoate in dosage forms. Unknown
6527278 The method was expanded to include sodium benzoate (IV), a preservative found in some liquid formulations. unknown
6279819 Interaction of theobromine with sodium benzoate. Unknown
6279819 The interaction of theobromine with sodium benzoate was investigated by PMR spectroscopy. unknown
6279819 Chemical shifts of theobromine protons were determined as a function of sodium benzoate concentration in deuterium oxide at 30 and 15 degrees. unknown
6279819 Signals of both methyl groups of theobromine underwent significant upfield shifts when sodium benzoate was added to a theobromine solution. unknown
6985202 Antiatherogenic activity of cetaben sodium, sodium p-(hexadecylamino) benzoate, in the aortae of hypercholesteremic rabbits subjected to aortic endothelial cell desquamation. Rabbits
6985202 The effects of sodium p-(hexadecylamino)benzoate [cetaben sodium] on plasma sterol concentrations, aortic sterol deposition and the incidence of atherosclerotic lesions in cholesterol-fed rabbits subjected to aortic deendothelialization with a balloon catheter have been studied. unknown
6604816 The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. Rats
6197661 Addition of alpha-tocopherol, acetylsalicylic acid, sodium benzoate or ascorbic acid to the culture medium afforded a concentration-dependent modification of lysosomal response to HU treatment. Mice
4080498 By the end of 1982, theophylline previously given in alcoholic solution (osmolality greater than 4000 mosm/kg) was given in a preparation of sodium benzoate isoosmotic to the plasma; in addition, blood was irradiated for 20 minutes by X-Rays (5000 rads) before every transfusion. Human
3723360 The effect of sodium salicylate on the concentration-dependent association of methylene blue as expressed by metachromasy was observed and compared with the effects of other additives: urea, sodium chloride, sodium acetate, sodium sulfate, and sodium benzoate. unknown
3735587 Effect of caffeine sodium benzoate, ketamine hydrochloride, and yohimbine hydrochloride on xylazine hydrochloride-induced anorexia in white-tailed deer. Deer
3735587 Fifteen male white-tailed deer (Odocoileus virginianus) were administered xylazine hydrochloride (1 mg/kg BW i.m.), xylazine hydrochloride (1 mg/kg i.m.) followed by caffeine sodium benzoate (10 mg/kg i.m.), xylazine hydrochloride (0.5 mg/kg i.m.) and ketamine hydrochloride (4.5 mg/kg i.m.), and xylazine hydrochloride (1 mg/kg i.m.) followed by yohimbine hydrochloride (0.125 mg/kg i.m.), in a Latin Square design. unknown
3735587 The percent decreases in DMI on the first 24-hr period after immobilization were: xylazine hydrochloride 47%, xylazine hydrochloride/caffeine sodium benzoate 36%, xylazine hydrochloride/yohimbine hydrochloride 36%, and xylazine hydrochloride/ketamine hydrochloride 31%. unknown
3561531 Effects of some antianginal and vasodilating drugs on sodium influx and on the binding of 3H-batrachotoxinin-A 20-alpha-benzoate and 3H-tetracaine. Rats
3572028 The results showed that, in humans and rats, there exists the same rank order in total absorption: benzoic acid sodium salt less than caffeine less than benzoic acid less than acetylsalicylic acid. Human
Rats
3631318 Caffeine sodium benzoate (500-2000 mg) was administered intravenously 10 minutes before ECT, and seizure duration was compared with that of a previous treatment unmodified by caffeine. Human
3355598 In the present study the degree and the mode of association of the radiolabelled drugs acetylsalicylic acid, sodium salicylate, and sodium benzoate with leucocytes were studied in view of the hypothesis that leucocytes are target cells for the anti-inflammatory activity of drugs. Human
3355598 The overall association rate of acetylsalicylic acid is larger than that of sodium salicylate and sodium benzoate at 37 degrees, but smaller at 4 degrees. unknown
3355598 The ratio of the intracellular to the extracellular concentration varied between 1 and 2 for sodium salicylate and sodium benzoate, and between 3 and 6 for acetylsalicylic acid. unknown
3355598 Lysis of cells decreases the association of acetylsalicylic acid and enhances the association of sodium salicylate and benzoate at 37 degrees twofold. unknown
3191161 Cytotoxicity of 6-O-palmitoyl ascorbic acid is also appreciably attenuated by singlet oxygen (1O2) scavengers such as hydroquinone, 1,4-diazobicyclo-2,2,2-octane or sodium azide, but not by hydroxyl radical scavengers including butylated hydroxytoluene, D-mannitol, benzoic acid and ethanol. unknown
2768186 Members of the benzoate group of chemoattractants stimulated the methylation of a P. putida polypeptide with an apparent molecular weight of 60,000 in sodium dodecyl sulfate-polyacrylamide gels. unknown
2777310 Model biological microemulsions: Part I--Phase behaviour and physicochemical properties of cholesteryl benzoate and sodium deoxycholate contained microemulsions. Unknown
2777310 Phase behaviour and some physicochemical properties of cholesteryl benzoate-contained microemulsions of xylene and heptane with water using sodium deoxycholate and butan-1-ol as surfactant and co-surfactant respectively have been studied. unknown
2778659 In this work, hydrotropic agents such as sodium benzoate, sodium o-hydroxybenzoate (sodium salicylate), sodium 2,5-dihydroxybenzoate (sodium gentisate), and the sodium salts of 2,4-dihydroxy- and 2,6-dihydroxybenzoic acid and of 2,4,6-trihydroxybenzoic acid have been used as alternative solubilizers of etoposide. Human
2778659 The weakest and strongest interactants with etoposide were, respectively, sodium benzoate and sodium 2,4,6-trihydroxybenzoate. unknown
2794777 Rat livers were perfused by the nonrecirculating technique with medium containing [15N]glycine and sodium benzoate. unknown
2800537 Enzyme formation was enhanced by sodium benzoate, and was markedly inhibited by glucose, maltose and glycerol. Unknown
2800537 When the organism was grown in 0.15% sodium benzoate medium (pH 6.8-7.0) at 30 degrees C for 72 hours, about 10 units of catechol 1,2 dioxygenase per ml was obtained. unknown
2610332 Two children reacted to tartrazine, three to sodium benzoate, two to sodium glutamate, two to sodium metabisulfite, four to acetylsalicylic acid and one to tyramine. unknown
2626838 To evaluate the incidence of hypersensitivity to aspirin and food additives, 36 subjects with bronchial asthma, 33 of whom were non-allergic asthmatics and 3 were allergic asthmatics who had a history of aspirin sensitivity, were challenged orally with six compounds: acetylsalicylic acid (ASA), sodium bisulfite, tartrazine, sodium benzoate, 4-hydroxy benzoic acid, and monosodium L-glutamate. Human
2673187 The MIC50 of these drugs in increasing order was less than or equal to 2 ppm GV-11, 6 ppm gentian violet, less than 16 ppm amphotericin B, 16 ppm hyamine 1622, 25 ppm econazole, 35 ppm chlorohydroxyquinoline, 40 ppm nystatin, 64 ppm miconazole, 747 ppm malachite green, 1550 ppm benzoic acid, 1536 ppm copper sulfate, 3144 ppm Monoprop, 4951 ppm Mold Zap, greater than 16,384 ppm propionic acid, and greater than 16,384 ppm sodium propionate. Candida
Candida albicans
Chickens
2691169 A rinse was prepared based on the principles applied to formulation of products for cleansing biologic surfaces, including anionic and nonionic surfactants, sodium benzoate, and auxiliary cleansing agents. Human
2515680 At 0.01 M either sorbitol or fructose inhibited alpha-amylase by 8%, Maltose 7%, sucrose 6%, phenol, glucose and galactose each by 5%, ethanol, glycerol, arabinose and sodium benzoate each by 4%, isopropanol and mannitol 1%, but methanol and ammonium citrate dibasic did not inhibit alpha-amylase. unknown
2539455 CD-1 mice were treated with caffeine-sodium benzoate solution (caffeine doses: 0, 5, 15 or 30 mg/kg i.p.) to determine plasma and brain concentrations, effects on benzodiazepine receptor binding based on specific uptake of a high affinity ligand, and locomotor activity. Mice
2545552 In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO. unknown
2560462 Inhibition by sodium azide and sodium benzoate indicated that these oxygen metabolites could be derived from the MPO-halide system but also from hydroxyl radical production. unknown
2421566 We relate our experiences about the number of exacerbations that certain food preservatives such as sorbic acid, benzoic acid, sodium benzoate, metabisulfite and sodium nitrate can provoke in 62 patients affected with ASA-triad in steroid dependent intrinsic asthma with nasal polyps and acute bronchospasm caused by aspirin ingestion, and in 80 patients with chronic urticaria (C.U.) as well as the first assays of the possible usefulness of the HRT (Histamine release test automatized using whole blood) for the etiologic diagnosis process. Human
2421566 Successive dilutions were incubated for 30 minutes using: pyrazolones, acetylsalicylate of lysine, sodium salicylate, sodium benzoate and 4-hydroxybenzoic acid which did not produce liberation of histamine in 100 controlled individuals. unknown
2421566 We have not observed any significant descent of the FEV1 with benzoate and salicylate in our group of 62 patients with ASA-triad, nor any manifestations presented with sodium metabisulfite, sodium nitrate and sorbic acid.(ABSTRACT TRUNCATED AT 250 WORDS) unknown
2570065 The Glu-204 and Phe-224 mutant DAOs showed comparable enzyme activities to that of the wild type enzyme, and were inhibited strongly by sodium benzoate, a potent competitive inhibitor of DAO. unknown
2576735 Specific binding of [3H]BTX-B was observed in the presence of 140 mM sodium or potassium and was inhibited by choline ion. unknown
2442717 (4.) 4-amino ethyl benzoate (benzocaine) had actions on the sodium current which were very similar to those of benzene with the exception that the rate of inactivation was scarcely affected and, at comparable shifts, the slope of the steady state inactivation curve was slightly smaller. unknown
3087136 This effect of 6-hydroxydopamine was prevented by either of the hydroxyl radical scavengers, sodium benzoate and mannitol, but not by the non-scavenger, urea; ninhydrin was partially protected against by mannitol but not by benzoate. Mice
3130627 Me2TU dioxide formation correlated with Me2TU consumption as a function of added H2O2 concentration and was prevented by simultaneous addition of catalase (but not boiled catalase), superoxide dismutase, dimethyl sulfoxide, mannitol, or sodium benzoate. Human
3136944 The agents tested included: reduced glutathione (GSH), butylated hydroxyanisole, vitamin E, copper(II) (3,5-diisopropylsalicylate)2, sodium benzoate, N-acetyl cysteine and disulfiram. Mice
2990218 With respect to the former, treatment of rats with iron chelators (deferoxamine mesylate, 2,3-dihydroxybenzoic acid), with scavengers of hydroxyl radical (dimethyl sulfoxide, dimethyl thiourea, sodium benzoate), or with vitamin E affords a significant degree of protection from acute lung injury as assessed by changes in lung vascular permeability and by morphologic parameters. unknown
2996587 Chemical modification of the CuA center in cytochrome c oxidase by sodium p-(hydroxymercuri)benzoate. Cattle
2996587 We have studied the reaction of cytochrome oxidase with sodium p-(hydroxymercuri) benzoate (pHMB) and found that the reaction proceeds, under appropriate conditions, to give an excellent yield of a particular derivative of the CuA center that has electron paramagnetic resonance and near-infrared absorption spectroscopic properties which are distinctly different from those of the unmodified center. unknown
2998601 The signal of the DMPO adduct obtained in the H2O2-MNNG-DMPO system disappeared on addition of the .OH scavenger sodium benzoate. Unknown
3018065 Addition of increasing concentrations of hydrogen peroxide (H2O2) caused progressive decreases in dimethylthiourea (DMTU) concentrations which were inhibitable by simultaneous addition of catalase, but not the superoxide anion (O2-.) scavenger, superoxide dismutase (SOD), or hydroxyl radical (.OH) scavengers, such as mannitol, sodium benzoate or dimethyl sulfoxide (DMSO). Unknown
3016234 Interactions in the solid state. II: Interaction of sodium bicarbonate with substituted benzoic acids in the presence of moisture. Unknown
3016234 It was found that high concentrations of substituted sodium benzoate were generated very quickly and affected the solubility of the reactants, diffusion coefficient of the acid, and the carbonic acid dehydration rate constant. unknown
3029606 The appearance rates of antipyrine, benzoic acid, benzylamine, urea, and alpha-methyl-D-glucoside (MG) in jejunal venous blood of anesthetized rats were measured with and without dietary fibers methylcellulose, carboxymethylcellulose sodium, guaran, and sodium alginate in the luminal solution. Rats
2861222 Thirty-four patients (17 with asthma and 17 with urticaria), whose case history suggested such intolerance, were challenged orally with increasing doses of seven compounds: acetylsalicylic acid, glafenine, sodium benzoate, sulfur dioxide, potassium sorbate, sodium glutamate, and tartrazine. Human
2861222 Thirty-four patients (17 with asthma and 17 with urticaria), whose case history suggested such intolerance, were challenged orally with increasing doses of seven compounds: acetylsalicylic acid, glafenine, sodium benzoate, sulfur dioxide, potassium sorbate, sodium glutamate, and tartrazine. Human
3699962 Double-blind, placebo controlled challenge tests with benzoic acid butylhydroxytoluene, butylhydroxyanisole, beta-carotene, beta-8-apo-carotenal, and sodium metabisulfite were made in 44 cases of chronic urticaria, 91 cases of atopic dermatitis, and 123 cases of contact dermatitis, as a comparison group. Human
2866337 In the third patient, prompt initiation of aggressive haemodialysis and intravenous sodium benzoate and sodium phenylacetate infusion successfully controlled plasma ammonium levels until they spontaneously resolved. Human
3570697 Treatment of these animals with the antioxidants superoxide dismutase, catalase, and sodium benzoate resulted in marked reduction of uveal inflammation. unknown
3007482 Hydroxyl radical scavenging agents (mannitol, sodium formate, sodium benzoate) did not attenuate the stimulation of activity observed with Fe-H2O2. unknown
3094191 Effects of a new imidazole derivative, sodium 4-[alpha-hydroxy-5-(imidazolyl)-2-methylbenzyl]-3,5-dimethyl benzoate dihydrate (Y-20811), on thromboxane (TX) production and platelet aggregation were investigated. Guinea Pigs
Human
Rabbits
Sheep
3613839 Also effective were allopurinol and oxypurinol, inhibitors of xanthine oxidase, but not superoxide dismutase (SOD) and hydroxyl radical scavengers, such as sodium benzoate and dimethyl sulfoxide (DMSO). unknown
3613839 BHT, quercetin, quinacrine and sulfhydryl compounds such as reduced glutathione and cysteamine which offer gastroprotection in vivo against ethanol inhibited lipid peroxidation induced in vitro by ferrous ion in porcine gastric mucosal homogenate, but SOD, sodium benzoate, DMSO, allopurinol and oxypurinol did not. unknown
3316936 Results obtained indicated that pasteurization at 60 degrees and 80 degrees C for 20 to 40 min, freezing at -5 degrees C, and addition of sodium benzoate at a concentration of 0.1 to 0.4% (w/v) could form a microbiological basis for the preservation of the juice for 1 month. Bacteria
3391940 Adulteration of products with sodium benzoate-fortified pulpwash or grapefruit juice can be detected by this method. unknown
3243888 A technique for the simultaneous determination of sorbic acid, benzoic acid, dehydroacetic acid, p-hydroxybenzoic acid esters (ethyl, isopropyl, n-propyl, isobutyl and n-butyl p-hydroxybenzoate) and saccharin sodium using ion-pair reversed-phase high-performance liquid chromatography is described. Soybeans
2843051 A second hydroxyl radical scavenger, sodium benzoate, had a similar protective effect on renal function (as measured by both BUN and creatinine). unknown
2982209 It has been found that, in the suitable concentration of the protecting agent, a substantial protective effect of sodium benzoate, acetylosalicylic acid, alpha-tocopherol, ascorbic acid, catalase, peroxidase or superoxide dismutase can be achieved. Human
3987036 During a low-arginine diet, together with sodium benzoate therapy, the plasma and cerebrospinal fluid arginine values returned to normal. unknown
3989683 Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts. II: Salicylic acid, theophylline, and benzoic acid. Unknown
4018545 Sodium benzoate in doses which do not possess antisecretory properties, produced a dose-dependent reduction of ethanol-induced gastric lesions in the rat. Rats
4018545 Indomethacin pretreatment antagonized sodium benzoate-ulcer reducing properties indicating that this latter acts, at least in part, through stimulation of prostaglandins synthesis. unknown
4030654 Liquid chromatographic determination of quinine, hydroquinine, saccharin, and sodium benzoate in quinine beverages. Unknown
4030654 A liquid chromatographic (LC) method is described for the determination of quinine, hydroquinine, sodium saccharin, and sodium benzoate in soft drinks. unknown
4030654 The proposed procedure is accurate and rapid and can also detect hydroquinine (a natural contaminant of quinine), sodium saccharin, and sodium benzoate. unknown
4030654 Linear responses ranged from 0.45 to 20 micrograms/mL for hydroquinine, from 54.8 to 219 micrograms/mL for sodium saccharin, and from 10.1 to 145.1 micrograms/mL for sodium benzoate. unknown
4030654 The reproducibility of the LC method was evaluated with standard solutions of hydroquinine, sodium saccharin, and sodium benzoate, which produced relative standard deviations of 0.42, 0.46, and 1.13%, respectively. unknown
4030654 The average recoveries for sodium saccharin and sodium benzoate from spiked samples were 99.4 and 100.2%, respectively. unknown
4033507 The incidence of reactions to tartrazine, sodium benzoate and yeast (7%) was not significantly different from those to the lactose placebo (9%). Human
4050860 We describe the successful use of sodium benzoate in a neonate with hyperammonemia associated with congenital lactic acidosis caused by a partial deficiency of the E1 component of pyruvate dehydrogenase (PDH); of note, this biochemical disturbance has not been previously described in PDH deficiency. unknown
4050860 Sodium benzoate, 250 mg/kg, was infused intravenously with a decrease in plasma ammonia of 25 micrograms/dl/hr. unknown
4050860 In our patient sodium benzoate was rapidly effective in producing a decline in plasma ammonia that was associated with clinical improvement. unknown
4053389 Benzoylalanine: detection and identification of an alanine conjugate with benzoic acid in hyperammonemic patients treated with sodium benzoate. Human
4053389 Urine of four hyperammonemic patients who were treated with large amounts of sodium benzoate were analyzed. unknown
3958802 Intraperitoneal injection of sodium benzoate to young ferrets fed arginine-free diet failed to decrease serum ammonia levels. unknown
3700530 Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen, codeine phosphate, and sodium benzoate in elixirs. Unknown
3700530 A stability-indicating high-performance liquid chromatographic method has been developed for the simultaneous determination of acetaminophen, codeine phosphate and sodium benzoate in an elixir formulation. unknown
3700530 The method has been validated for use with elixirs containing 120 mg of acetaminophen, 12 mg of codeine phosphate and 7.5 mg sodium benzoate preservative per 5 ml. unknown
3706242 In three patients with nonketotic hyperglycinemia, the oral administration of sodium benzoate in dosages designed to lower the cerebrospinal fluid concentration of glycine was followed by an abrupt change from frequent major seizures before treatment to no seizures, or only occasional minor ones, after treatment. Human
3716614 Sodium benzoate or potassium sorbate (100, 200, 300 and 400 mg/l) were added to cultures of Aspergillus parasiticus NRRL 2999 on apple juice (from syrup) and incubated quiescently at 25 degrees C for 3, 6, 9, 12 or 15 days. Aspergillus
3716614 Sodium benzoate, at all concentrations, suppressed fungal growth and stimulated the biosynthesis of G1, whereas little influence was exerted upon the accumulation of B1. unknown
3717115 This report describes a new therapeutic approach to the treatment of adults with portal systemic encephalopathy using sodium benzoate and sodium phenylacetate, two compounds that increase conjugated nitrogen excretion in the urine and that have been shown to be an effective treatment for children with congenital hyperammonemia. Human
3724834 In defined medium, benzoic acid (2 and 3 mg/ml), cinnamon (1 mg/ml), and sodium acetate (5 mg/ml) were fungitoxic. Aspergillus
3724834 Sodium benzoate (1, 2, 4 and 8 mg/ml) added after 2 days growth inhibited aflatoxin production in two defined media. unknown
3741416 The effect of sodium benzoate on ammonia toxicity in rats. Rats
3741416 At 9.5 mmoles/kg body weight, sodium benzoate sharply increased mortality in rats subsequently challenged with ammonia. unknown
3091026 Significance of transported glycine in the conjugation of sodium benzoate in spf mutant mice with ornithine transcarbamylase deficiency. Mice
3091026 3H-glycine and 14C-serine were injected intraperitoneally, during treatment of spf mutant mice with 2% sodium benzoate in drinking water. unknown
3769993 She received only brief treatment with sodium benzoate from 11-15 months and at 15 years of age is profoundly retarded and has epilepsy. Human
3769993 The younger sister was diagnosed 36 h after birth, was treated with strychnine, sodium benzoate and arginine from the neonatal period and at 27 months of age is only moderately retarded and free of seizures. unknown
3778687 The tryptophan uptake into forebrain and brainstem was measured in urease-injected rats and in controls after prior application of sodium benzoate or hippurate. unknown
3539408 In some cases of chronic urticaria it is suspected that food additives such as tartrazine and sodium benzoate or salicylates may play a role in the pathogenesis of the condition. Human
3539408 It was found that significant production of LIF occurred in response to tartrazine and sodium benzoate in those individuals with chronic additive induced urticaria. unknown
3102706 The rate-limiting step for hippurate synthesis from sodium benzoate (NaB) was investigated in growing rats. unknown
3593373 The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitine. Mice
3593373 Sodium benzoate has been recommended and even been used for the treatment of hyperammonemia in humans. unknown
3593373 More recently, a note of caution was raised since it has been shown that in experimental animals, sodium benzoate potentiates ammonia toxicity and inhibits urea synthesis in vitro. unknown
3593373 In hyperammonemia, urea production and N-acetylglutamate levels were decreased by sodium benzoate. unknown
3593373 Pretreatment of mice with L-carnitine suppressed mortality following ammonium acetate plus sodium benzoate administration. unknown
2956550 Modulation of experimental phacoanaphylactic endophthalmitis with the antioxidants sodium benzoate, and 2,3-dihydroxybenzoic acid. Rats
2956550 The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. unknown
2887046 Cytotoxicities of sodium benzoate in primary culture of hepatocytes from adult rat liver. Rats
2887046 The cytotoxicities of sodium benzoate was studied using primary culture of hepatocytes established from adult rat liver by a collagenase perfusion technique and maintained as a monolayer in serum-free culture medium. unknown
2887046 The activities of ornithine transcarbamylase (as a marker of mitochondria) and tyrosine aminotransferase (as a marker of cytosol) were clearly suppressed by sodium benzoate at concentration in excess of 500 micrograms/ml. unknown
3625489 For each anatomic site, 1,000 nmol of 14C-radiolabeled benzoic acid, benzoic acid sodium salt, caffeine, or acetylsalicylic acid was applied to 1-cm2 area of skin of male Caucasian patients aged 28 +/- 2 years (groups of 6-8). Human
3676243 An oral dose of 4-10 g sodium benzoate was given to six normal adults to deplete the metabolic pool of glycine, and the urinary excretion of 5-oxoproline was followed for 6 h. unknown
3326732 Long-term alternate pathway therapy, using sodium benzoate and sodium phenylacetate, has generally been unassociated with signs of toxicity. Human
3090179 Further, introduction of an intracellular oxygen centered radical (OCR) scavenger, sodium benzoate, for the hydroxyl (.OH) radical was observed to affect cyclooxygenase metabolism in a dose-response manner. unknown
3090179 At higher concentrations of sodium benzoate, i.e., 10(-2) M, TxB2 production was inhibited; in contrast, 10(-3) M sodium benzoate enhanced neutrophil TxB2 generation which was particularly marked during times of increased oxidative burst activity, i.e. unknown
3123518 In separate experiments, treatment with two other hydroxyl radical scavengers (dimethyl sulfoxide or sodium benzoate) and a second iron chelator (2,3,dihydroxybenzoic acid) had a similar protective effect on renal function (as measured by both BUN and creatinine). unknown
2828626 Quenchers of hydroxyl radical (.OH), dimethylsulfoxide and sodium benzoate, had less effect, and required higher concentrations. unknown
2831737 A second hydroxyl radical scavenger, sodium benzoate (150 mg/kg ip twice a day), also resulted in marked reduction in proteinuria (day 5: anti-Fx1A 56 +/- 7, n = 9; anti-Fx1A + benzoate, 14 +/- 4 mg/24 h, n = 8, P less than 0.01). unknown
3348818 Mitochondrial urea cycle enzymes in rats treated with sodium benzoate. Rats
3348818 Since sodium benzoate, which is widely used to treat hyperammonemia its effect on mitochondrial urea cycle enzymes was investigated. its effect on mitochondrial urea cycle enzymes was investigated. unknown
3348818 Sodium benzoate was administered to urease treated hyperammonemic rats and controls. unknown
3360879 For patients with inborn errors of urea synthesis, oral administration of sodium benzoate is the usual treatment to increase the nitrogen excretion. unknown
3360879 The preliminary plasma concentration-time and urinary excretion rate-time profiles of hippuric acid and benzoic acid from a healthy subject receiving small, medium and large doses of sodium benzoate are reported. unknown
3374991 Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse. Human
Mice
3374991 Herein we examine the effects of sodium benzoate and sodium phenylacetate on feeding and central serotonin turnover in a child with citrullinemia and in an animal model of congenital hyperammonemia, the ornithine transcarbamylase-deficient sparse-fur (spf/y) mouse. unknown
3374991 In the mouse, sodium benzoate had a biphasic effect on both plasma ammonium levels and brain serotonin turnover. unknown
3379590 In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. Unknown
3190922 Sodium benzoate inhibits fatty acid oxidation in rat liver: effect on ammonia levels. Rats
3190922 Sodium benzoate inhibited PC and octanoic acid-mediated State 3 respiration rates by 39 and 29%, respectively, at 0.5 mM in isolated rat liver mitochondria. unknown
3190922 Administration of sodium benzoate to rats caused a dose-dependent increase in hepatic ammonia levels. unknown
3190922 Our results warrant a reevaluation of the use of sodium benzoate in the treatment of hyperammonemia. unknown
3196567 In batch mock solution tests, the addition of sodium benzoate resulted in a 69% equilibrium bilirubin removal at 50 mM and 96% removal at 100 mM. Human
3196567 During flow tests, adsorptive removal of sodium benzoate was so rapid that the CAC had to be pretreated with sodium benzoate solutions. unknown
3196567 In the absence of sodium benzoate, the outlet bilirubin was 50% of the inlet concentration at the passage of one void volume, with a rapid increase to 70% (30% removal). unknown
3196567 With sodium benzoate at 100 mM, the same 50% outlet/inlet percent was observed at one void volume throughput, but the outlet concentration fell to 6% of the inlet at 12 column void volumes (94% removal). unknown
3196567 A significant decrease in platelet aggregation was measured with the addition of sodium benzoate, which makes this augmented hemoperfusion removal of bilirubin clinically attractive. unknown
2848972 Concurrent administration of hydroxyl radical scavengers dimethylthiourea, (DMTU 500 mg/kg followed by 125 mg/kg i.p. twice a day) and sodium benzoate (BENZ, 150 mg/kg followed by 125 mg/kg i.p. twice a day) starting the evening before PAN injection markedly reduced proteinuria throughout the course of the study (urinary protein, mg/24 hours on day 7, mean +/- SEM: PAN: 229 +/- 45, N = 15; PAN + DMTU: 30 +/- 5, N = 18; PAN + BENZ: 80 +/- 18, N = 16. Because of the participation of iron in biological systems to generate hydroxyl radical, we also examined the effect of deferoxamine (DFO, 30 mg/day), an iron chelator, on the PAN-induced proteinuria. Rats
3230118 High-pressure liquid chromatographic assay of dextromethorphan hydrobromide, guaifenesin, and sodium benzoate in an expectorant syrup. Unknown
3230118 An ion-pair reversed-phase high-pressure liquid chromatographic assay is developed that allows simultaneous quantitation of guaifenesin, dextromethorphan hydrobromide, and sodium benzoate in an expectorant syrup. unknown
3230118 Average recoveries of 99.6, 99.8, and 99.7% with relative standard deviations of 0.5, 0.9, and 0.2% are obtained for guaifenesin, dextromethorphan hydrobromide, and sodium benzoate, respectively, from laboratory prepared samples. unknown
3230118 Chromatographic conditions are selected to afford a pH that provides adequate separation of guaifenesin, dextromethorphan hydrobromide, sodium benzoate, and sodium saccharin and a detection wavelength that effectively compensates for the great disparity in quantity between guaifenesin and dextromethorphan hydrobromide present in syrups. unknown
3230118 The retention profiles for sodium saccharin, guaifenesin, sodium benzoate, and dextromethorphan hydrobromide in the apparent pH range of 2.5 to 6.6 are established. unknown
2970535 Mesaconic aciduria in patients treated with sodium benzoate. Human
3420810 Metabolism of aminopyrine, sodium benzoate and toxicity of cyclophosphamide were studied in 185 male rats under conditions of various content of vitamin B1 in the animals. Rats
2914434 Immediate contact reactions to benzoic acid and the sodium salt of pyrrolidone carboxylic acid. Comparison of various skin sites. Human
2914434 Benzoic acid (BA) and the sodium salt of pyrrolidone carboxylic acid (NaPCA) were tested in 13 healthy persons to obtain information about, firstly, the irritant properties of NaPCA and, secondly, the reactivity of various skin sites. unknown
2492793 Inhibition of pyruvate carboxylase by sequestration of coenzyme A with sodium benzoate. Rats
2492793 Pyruvate-dependent CO2 fixation by isolated mitochondria was strongly inhibited by sodium benzoate. unknown
2713151 Failure of sodium benzoate to alleviate plasma and liver ammonia in rats. Rats
2713151 Subsequent injection of sodium benzoate failed to alleviate ammonia levels, and on the contrary, caused a further increase. unknown
2713151 Sodium benzoate itself, when administered, resulted in higher levels of ammonia in plasma and liver of the rats. unknown
2713151 Administration of glycine to rats treated with benzoate did not lower ammonia levels indicating that other factors besides glycine may also be necessary for the removal of sodium benzoate. unknown
2726204 We present a case of Melkersson-Rosenthal syndrome that occurred in an adult patient who experienced intolerance to the food additives sodium benzoate and tartrazine. Human
2736427 Alleged food-additive intolerance (respiratory, dermatological, behavioural or abdominal) was assessed in 19 children using daily challenge drinks of either, base product alone, base product plus sunset yellow/tartrazine, or base product plus sodium metabisulphite/sodium benzoate. Human
2616384 The intragastric administration of 1 ml of 40 vol.% ethanol solution decreased the PD by 39%, of 10 mg of caffeine sodium benzoate by 22% and the simultaneous administration of alcohol and caffeine by 53%. unknown
2841019 In both cell lines, a significant inhibition of Dox toxicity was found after treatment with the hydroxyl radical scavengers, N-acetylcysteine, sodium benzoate and dimethyl sulfoxide, but not with mannitol. unknown
2986638 This breakage was completely inhibited by a .OH radical scavenger (sodium benzoate) and by catalase, but only slightly by superoxide dismutase. unknown
4005264 Reaction of alpha-L-fucosidase with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and sodium p-(hydroxymercuri)benzoate resulted in complete inactivation of the enzyme. unknown
2978951 The antifungal effects of sodium chloride, sorbic acid and sodium benzoate and the combined use of oregano with sodium chloride were also tested under the same conditions for comparison. Fungi
2744016 Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate. Mice
2744016 Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. unknown
2744016 Pretreatment of mice with carbamyl glutamate, a structural analogue of N-acetyl glutamate, decreases mortality induced by ammonium acetate and sodium benzoate administration. unknown
2745145 Peritoneal dialysis was instituted, but the metabolic crisis could only be overcome by the following therapeutic measures: restriction of protein intake to 1.5 g/kg/d in part as a special aminoacid mixture, in part as breast milk; sufficient caloric supply (600-500 kJ/kg/d); sodium benzoate 350 mg/kg/d: arginine 2 mmol/kg/d respectively citrulline 350 mg/kg/d, and carnitine 150 mg/kg/d. unknown
2765416 It appeared that (1) catalase and the hydroxyl radical scavengers, dimethylsulphoxide and sodium benzoate, inhibited the hydroxylation, whereas Fe2+ and H2O2 potentiated it; (2) pretreatment of MMMFs with the iron chelator, deferoxamine, or with extensive heat (200-400 degrees C), attenuated the hydroxylation; (3) the hydroxylation obtained by various MMMFs varied considerably; (4) there was no apparent correlation between the hydroxylation and the surface area of different MMMFs, although increasing the surface area of a fibre by crushing it increased its hydroxylating capacity; and (5) there was good correlation between the hydroxylation of dG residues in DNA and the hydroxylation of pure dG in solution for the 16 different MMMFs investigated. Unknown
2818615 Daily intraperitoneal injections of sodium benzoate in increasing concentrations (125-375 mg/kg), given between 17 and 21 days, did not cause any induction in spf/Y or +/Y mice. unknown
2602245 Investigations revealed profound hyperammonaemia, which responded to treatment with sodium benzoate and sodium phenylacetate. Human
2609332 Benzoylcarnitine was identified in the urine of a patient with a carbamoyl-phosphate synthase I deficiency for whom sodium benzoate and L-carnitine had been used to treat hyperammonemia. Human
2609332 Its excretion in the urine was increased day by day at the administration of both sodium benzoate and L-carnitine from 0.10 to 2.25 mmol/g creatinine. unknown
2692930 Oral treatment with sodium citrate and sodium benzoate was very effective, though transiently, for disturbed consciousness in this case. unknown
2501586 Excretion of hippuric acid during sodium benzoate therapy in patients with hyperglycinaemia or hyperammonaemia. Human
2501586 In patients with non-ketotic hyperglycinaemia and two patients with urea cycle disorders treated with varying doses of sodium benzoate there was linear correlation between intake of benzoate and excretion of hippurate. unknown
2533792 Methylsuccinate and mesaconate in urine of patients treated with sodium benzoate. Human
2533792 Two unusual peaks were found on gas chromatography of urine from four hyperammonemic patients treated with sodium benzoate. unknown
2533792 Of the two unusual substances, methylsuccinate was found to be a contaminant of sodium benzoate administered for the treatment of hyperammonemia. unknown
2533792 However, mesaconate was not a contaminant of sodium benzoate, though it could be detected in all urine samples from hyperammonemic patients treated with sodium benzoate. unknown
2533792 Considering that mesaconate is an inhibitor of fumarase, the toxic effects of sodium benzoate may be attributable to the mesaconate. unknown
2533792 It is recommended that methylsuccinate-free sodium benzoate should be used for the treatment of hyperammonemia. unknown
2569515 Photon correlation spectroscopy indicated possible unfolding of BSA molecules in solutions of sodium benzoate and sodium salicylate at 25 degrees C. Unknown
2603302 Elimination of toxic substances from the lymph during lymphosorption was greater when using a vibration column, sorbent impregnation by sodium caffeine+-benzoate and ethanol treatment of the lymph. Human
2752390 Reagents employed were hydrogen fluoride-triethylamine complex, methanol in the presence of sodium hydrogencarbonate, sodium benzoate, sodium azide, potassium thiocyanate, and sodium borohydride. unknown
2749124 Thirty-three patients with chronic urticaria and angioneurotic edema whose case history suggested a possible link between exacerbations of the symptoms and ingestion of food additives or with acute exacerbations of the disease without any known triggering event were challenged orally in a double-blind study with increasing doses of the following additives: sodium benzoate, sodium metabisulfite and tartrazine and lactose as placebo. Human
2749124 Among 132 oral provocation tests 11 (8.3%) were positive (appearance of acute urticaria/angioneurotic edema): 5 (15.1%) to sodium benzoate, 4 (12.1%) to tartrazine an 2 (6%) to sodium metabisulfite. unknown
2344849 Caffeine sodium benzoate in doses of 0.0595-0.476 mmol/kg (11.55-92.4 mg/kg) distinctly reduced the anticonvulsant efficacy of PB, in the highest dose tested with an increase in ED50 value from 19.5 to 38 mg/kg. unknown
2344849 Generally caffeine sodium benzoate (up to 0.476 mmol/kg) did not affect the plasma levels of studied AEDs, and only at 0.476 mmol/kg did it significantly decrease the level of PHT. unknown
2210591 In addition to plasma exchange, hemodialysis and then peritoneal dialysis for next 5 days, parenteral sodium benzoate and arginine were administered. Human
2280019 Benzoic acid, an end product of enzymatic activity, was directly detected by high-performance liquid chromatography after 1 and 24 h of incubation in 1% sodium hippurate. Human
Legionella
2088211 In method B nucleophilic opening of 3'-deoxy-5'-O-(tert-butyldimethylsilyl)-5-methyl-2,2'-anhydrouridine+ ++ was carried out with sodium azide in hexamethylphosphoramide in the presence of benzoic acid. unknown
2171789 The DNA cleavage by PHQ was inhibited by superoxide dismutase (SOD), catalase and several oxygen radical scavengers such as polyethylene glycol, tert-butanol, dimethyl sulfoxide, sodium azide, sodium benzoate, bovine serum albumin and methionine. unknown
1964383 The inhibitory effects of a series of nonspecific local anesthetics on batrachotoxin-elicited sodium flux, batrachotoxin-elicited phosphoinositide breakdown, and on the binding of [3H]batrachotoxin-A 20 alpha-benzoate to sodium channels in guinea pig cerebral cortical synaptoneurosomes are shown to be well-correlated with the molecular size and the hydrophobic character of the molecules. unknown
1982201 AHR-13268D (4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]benzoic acid, sodium salt) is a potent, long-acting water soluble, antiallergic and antihistaminic agent. Guinea Pigs
Rats
1937145 Aq.T at 300 ng/microL extended 90% protection to human lymphocyte DNA against TDS-induced damage, and was more effective than the other protectants--DABCO, D-mannitol, sodium benzoate, vitamin E (ROS quenchers), SOD, CAT (antioxidant enzymes), tannic acid, flufenamic acid, BHA, BHT, n-PG, curcumin and quercetin (antioxidants). unknown
1789072 The usefulness of caffeine sodium benzoate with a 70-80% success rate and epidural blood patching with a 90%-plus success rate are discussed. Human
1795709 Scavengers and inhibitors of different activated oxygen species (sodium azide, sodium benzoate, catalase and superoxide dismutase) prevent the formation of breaks in full or partly. unknown
2303075 Therapy with sodium benzoate, L-arginine, essential amino acids, L-carnitine and peritoneal dialysis lowered the blood ammonia levels, and his clinical manifestations improved. Human
2326771 The effect of sodium 4-[alpha-hydroxy-5-(imidazolyl)-2-methylbenzyl]-3,5-dimethyl benzoate dihydrate (Y-20811), a selective thromboxane (TX) synthetase inhibitor, on endotoxin shock was investigated in comparison with aspirin. Rabbits
2381978 The investigation gave solubility values in the range between 0.002% (theobromine) and 26% (lidocaine), whereas benzoate, phenobarbital sodium and procaine hydrochloride are completely insoluble. Unknown
1337470 Male and female rats were given oestradiol benzoate (1 mg s.c. twice a week for 3 weeks) and/or sodium nitroprusside (SN), a donor of nitric oxide (NO), which was administered in their food in amounts of 0.2 or 0.6 mg/rat/day. Rats
2210018 We have studied the plasma and urinary levels of free and esterified carnitine in 18 patients affected by a primary defect of ammonia metabolism, which had been managed with or without a therapy of sodium benzoate. Human
2210018 The group treated with sodium benzoate showed a more profoundly disturbed plasma and urinary carnitine profile: a significantly lower plasma and urinary free carnitine, accompanied by a clearly increased esterified/free carnitine ratio. unknown
2082688 This new method has been applied to the assay of compound injection of sodium benzoate and caffeine and compound tablet of amidopyrine and caffeine with satisfactory results. Unknown
2083269 Addition of catalase and sodium benzoate strongly decreases the single-strand breaks formation. unknown
2132454 A rinse was prepared based on the principles applied to formulation of products for cleansing biologic surfaces, including anionic and nonionic surfactants, sodium benzoate, and auxiliary cleansing agents. Human
2178070 We present a male newborn infant who sustained this disorder and was managed successfully with blood exchange transfusion, peritoneal dialysis, supplemented with sodium benzoate and sodium bicarbonate therapy. unknown
2178070 Special designed formula was then given with restriction of protein intake and supplement with sodium benzoate and sodium carbonate. unknown
1677573 On the mechanism of inhibition of gluconeogenesis and ureagenesis by sodium benzoate. Rats
1677573 Synthesis of glucose from lactate and generation of urea from ammonia were inhibited when sodium benzoate was added to suspensions of rat hepatocytes. unknown
1863104 To study the effect of sodium benzoate on carnitine metabolism, the acylcarnitine profile in the urine of five normal volunteers and two patients with urea cycle disorders was examined with fast atom bombardment-mass spectrometry. unknown
1863104 The volunteer subjects were given 5 g of sodium benzoate orally and the two patients with urea cycle disorders (carbamyl phosphate synthetase deficiency type I and ornithine transcarbamylase deficiency) were already undergoing treatment with sodium benzoate and L-carnitine. unknown
1863104 The amount of benzoylcarnitine excretion depended on the dose of both sodium benzoate and L-carnitine in a reciprocal relation. unknown
1863104 Increased excretions of acetylcarnitine and propionylcarnitine were also noted after sodium benzoate administration. unknown
1863104 Supplementation with carnitine may be necessary to minimise the adverse effects of sodium benzoate treatment in hyperammonaemia. unknown
1917723 Sorbic acid, sodium benzoate, nisin, formaldehyde and lime at concentrations up to 500, 100, 1000, 1500 and 2000 ppm, respectively did not adversely affect the malting properties of sorghum grain. Bacteria
Fungi
1931156 Amino acids in the rat liver and plasma and some metabolites in the liver after sodium benzoate treatment. Rats
1931156 The effect of sodium benzoate administration on amino acids in the liver and plasma and various metabolites in the liver was studied. unknown
1657732 In reactions with 50 mM mannitol and 50 mM sodium benzoate, both of which are hydroxyl radical scavengers, adduct formation was significantly inhibited with adduct levels being 30 and 51% of control values, respectively. unknown
1658168 The hydroxyl radical scavengers dimethylthiourea (DMTU), sodium benzoate, and dimethylsulfoxide (DMSO) were administered to rats before doxorubicin hydrochloride (ADR) (5 mg/kg, IV) to probe the role of free radicals in mediating proteinuria in doxorubicin hydrochloride nephrosis (AN). Rats
1658168 Unlike DMTU, neither sodium benzoate nor DMSO reduced proteinuria in rats with AN.(ABSTRACT TRUNCATED AT 250 WORDS) unknown
1746956 Sodium benzoate was generally the least toxic, with an IC50 in the range of 1,225 to 32,400 mg/liter. unknown
1722783 A study was carried out on 29 patients to investigate the amount of histamine liberation and release of platelet-activating factor and 6-keto-prostaglandin F1 alpha from gastric mucosa and whole blood or mononuclear cells by sodium benzoate. Human
1722783 The release of histamine and prostaglandin from mucosa was significantly increased by sodium benzoate in comparison to the spontaneous release observed in patients. unknown
1722783 The mucosa of the control persons did not react to sodium benzoate. unknown
1804654 Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans. Human
1804654 Plasma concentration-time data for benzoic and hippuric acids and urinary excretion-time data for hippuric acid were analyzed simultaneously after oral doses of 40, 80 or 160 mg/kg sodium benzoate administered at least one week apart to 6 healthy subjects. unknown
1804654 The mean AUCs of benzoic acid after the doses of 80 and 160 mg/kg of sodium benzoate were 3.7- and 12.0-times greater, respectively, than after 40 mg/kg. unknown
1804654 The individual maximum rate of metabolism can be estimated from the urinary excretion rate of hippuric acid 1.5 to 3 h after the single oral dose of 80 to 160 mg.kg-1 sodium benzoate. unknown
1674808 Anaphylaxis with sodium benzoate. Human
1310595 Incubation of SIN-1 with both deoxyribose and sodium benzoate resulted in the formation of malondialdehyde (MDA). unknown
1310595 In addition, the incubation of SIN-1 with sodium benzoate resulted in the production of compounds with fluorescence emission spectra characteristic of hydroxylated products. unknown
1584743 Both the scavengers of OH (diazabicyclooctane and histidine) and those of 1O2 (mannitol and sodium benzoate) failed to inhibit the multiplication of Toxoplasma in macrophages that were incubated with either Obioactin, Lonomycin A, or MDP. unknown
1618465 Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial. Human
1618465 A prospective randomized double-blind study was conducted to evaluate the efficacy of sodium benzoate in the treatment of acute portal-systemic encephalopathy. unknown
1618465 Seventy-four consecutive patients with cirrhosis or surgical portasystemic anastomosis and hepatic encephalopathy of less than 7 days duration were randomized to receive lactulose (dose adjusted for 2 or 3 semiformed stools/day) or sodium benzoate (5 gm twice daily). unknown
1618465 Thirty-eight patients received sodium benzoate; 36 took lactulose. unknown
1618465 Thirty patients (80%) receiving sodium benzoate and 29 (81%) receiving lactulose recovered; the remaining patients died. unknown
1618465 The cost of lactulose for one course of therapy was 30 times that of sodium benzoate. unknown
1618465 We conclude that sodium benzoate is a safe and effective alternative to lactulose in the treatment of acute portasystemic encephalopathy. unknown
1383674 Characteristics of sodium benzoate injury of Listeria monocytogenes. Listeria monocytogenes
1383674 Over 99% of viable cells of Listeria monocytogenes were injured after exposure to a solution of 8.5% sodium benzoate (pH 7.0) for 1 h. unknown
1422942 Patients with a history of anaphylactoid reactions to drugs or food additives showed clinical symptoms such as urticaria, flush, nausea, dizziness and hypotension after oral provocation with cyanocobalamine, propyphenazone, acetylsalicylic acid and sodium benzoate. unknown
1483363 We gave intraperitoneal injections of sodium benzoate, sodium salicylate, sodium methylprednisolone and sodium phenobarbital for 4 consecutive days to groups of weanling guinea pigs before sacrifice. unknown
1483363 Sodium benzoate did not have any effect on benzoyl-CoA ligase activity or on in vitro hippurate synthesis. unknown
1352215 Benzolyglycine formation was investigated by following the disappearance of benzoic acid from blood and appearance of benzoylglycine in blood and urine after administration of sodium benzoate (0.2-2 mmol/kg, iv) to anesthetized rats whose urine formation was stimulated by mannitol administration. unknown
1374324 The following five chemicals were examined: sodium benzoate, aniline, diethylene glycol, pentaerythritol, and 4-nitrophenol. unknown
1374324 Sodium benzoate and aniline, which are known to be generally readily biodegradable consistently degraded in practically all tests, thus demonstrating the technical feasibility of the methods. unknown
8392491 CL and LDCL of activated PMNs was enhanced by aminotriazole, but strongly inhibited by diphenylene iodonium (an inhibitor of NADPH oxidase) by azide, sodium cyanide (CN), cimetidine, histidine, benzoate, DMTU and moderately by superoxide dismutase (SOD) and by deferoxamine LUCDCL was markedly inhibited only by SOD but was boosted by CN. unknown
8394268 DNA damage was blocked by catalase and by the scavenging agents dimethyl sulfoxide and sodium benzoate. unknown
8396391 Catalase (4000 U/ml), superoxide dismutase (300 U/ml), sodium azide (1 mM), sodium benzoate, mannitol, taurine and methionine (all 20 mM) were all unable to protect against the cytotoxic effects of cobalt ions and cobalt metal alone or mixed with tungsten carbide. unknown
8400025 The agents used were iodoacetate, superoxide dismutase, sodium benzoate, catalase and mannitol. Human
2043670 No significant inhibitory effect by superoxide dismutase, catalase and sodium benzoate on the complex induced lipid peroxidative reaction, suggesting little involvement of superoxide anion, hydrogen peroxide and hydroxyl radical in the reaction. unknown
1951305 Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. Human
1821455 Sensibilizating antibodies to pertussis antigen are statistically significantly more frequent than to other vaccinal antigens (diphtheria and tetanus toxoids) and additives contained in the vaccines (methiolate, sodium benzoate). Human
1356172 In the prospectively treated child, early therapy with intravenous sodium benzoate and sodium phenylacetate slowed the rate of increase in blood ammonia level, but this therapy did not prevent the need for peritoneal dialysis. Human
8438805 INTERVENTIONS--Intravenous sodium benzoate and sodium phenylacetate were more successful in reversing the coma than any other intervention. Human
4359211 NMR investigations of caffeine-sodium benzoate interactions. Unknown
4851126 Complexation of theophylline with sodium benzoate: an NMR study. Unknown
1249028 Determination of saccharin, sodium benzoate, and caffeine in beverages by reverse phase high-pressure liquid chromatography. Unknown
1249028 A reverse phase high-pressure liquid chromatographic method is presented for the simultaneous separation and determination of sacchrain, sodium benzoate, and caffeine in soft drinks, fruit juices, fruit cocktails, fruit punches, coffee, and artificial sweetener concentrates. unknown
1249028 The results of saccharin, sodium benzoate, and caffeine determinations in 34 soft drinks (representing 11 manufacturers and 20 flavors); 8 fruit juices, cocktails, and punches; 7 coffees; and 6 artificial sweetener concentrates are presented. unknown
1249028 Average recoveries of saccharin, sodium benzoate, and caffeine from soft drinks are 99.0, 99.3, and 100.2%, respectively. unknown
1275074 Five hundred milligrams of sodium benzoate were given hourly. unknown
1100092 The patients with reactions to aspirin were also tested with tartrazine, sodium benzoate, 4-hydroxybenzoic acid, sodium- and phenyl salicylate and the analgesics indomethacin, paracetamol and mefanamic acid. Human
807732 This dihydropteridine was oxidized with potassium permanganate, and the product was treated successively with sodium hydrosulfide to replace the benzylthio group and with aqueous sodium hydroxide to hydrolyze the ester function to give p-[[(2-amino-3,4-dihydro-4-thioxo-6-pteridinyl)methyl]methylamino]benzoic acid (N10-methyl-4-thiopteroic acid, 12). Enterococcus faecalis
Human
Mice
Pigeons
874803 All active and inactive ingredients (sodium benzoate and FD&C Yellow No. 5 dye) can be separated with high-pressure liquid chromatography except the two antihistamines, pheniramine maleate and pyrilamine maleate. unknown
895557 Sodium benzoate is suggested as an inhibitor of cellulose decomposing bacteria and fungi for detecting and counting micromonospores. Corn
Micromonospora
Wheat
422493 Recovery of sodium benzoate added to soy sauce ranged from 94 to 104%. Unknown
440838 The patient reported here has shown clinical and EEG improvement while taking strychnine in conjunction with sodium benzoate. unknown
447949 Forty-five patients with moderately severe perennial bronchial asthma were challenged by ingestion of: acetylsalicyclic acid (ASA); 4 azo dyes (tartrazine, sunset yellow, amaranth, and ponceau); 3 non-azo dyes (erythrosine, brilliant blue, and indigotin); sodium benzoate (NaB); parahydroxybenzoic acid (OHBA); butylated hydroxyanisole (BHA); and butylated hydroxytoluene (BHT). Human
457561 We have assessed the characteristics of oxygen transport following chronic intraperitoneal administration of sodium cyanate (NaCNO, 90 mg/kg; P50 decreased), o-iodosodium benzoate (OISB, 300 mg/kg; P50 increased), or sodium chloride (NaCl; P50 unchanged) to rats at a rate of 5 times/wk for 16 wk. Rats
458574 The weakest and strongest interactants with chartreusin were sodium benzoate and sodium trihydroxybenzoate, respectively, while the effect of mono- and dihydroxybenzoates was intermediate. Unknown
528049 Agents which are believed to scavenge the hydroxyl radical (.OH), sodium benzoate, and mannitol, as well as scavengers of superoxide anion (O2-) or hydrogen peroxide, decreased C2H4 production, implicaing .OH as the oxidizing radical. Human
528441 High pressure liquid chromatographic determination of sodium saccharin, sodium benzoate, and caffeine in soda beverages: collaborative study. Unknown
528441 A collaborative study for the determination of sodium saccharin, sodium benzoate, and caffeine in 3 types of soda beverage, cola, grape, and lemon-lime, has been completed using reverse phase high pressure liquid chromatography with a muC18 column and acetic acid mobile phase. unknown
528441 Recoveries for sodium saccharin were 98.6, 98.0, and 99.1%; for sodium benzoate, 100.6, 102.6, and 100.6%; and for caffeine, 100.8, 101.4, and 101.1%, respectively. unknown
531053 Early treatment of severe infantile glycine encephalopathy (nonketotic hyperglycinemia) with strychnine and sodium benzoate. Human
547491 Urticarial reactions were seen after administration of p-hydroxybenzoic acid methylester (5), p-hydroxybenzoic acid propylester (6), benzoic acid (9), sodium benzoate (6), tartrazine (6). Human
127058 Of the drugs examined, sodium salicylate, sodium benzoate and indomethacin caused a significant increase in the concentration of serum free tryptophan and stimulated the synthesis of 5-HT in the brain. unknown
136341 Estrogen (EB) and EB + progesterone (P) induced changes in pituitary sodium, potassium adenosine triphosphatase activity (ATPase). Rats
147520 Topical treatment with 1% Pimafucin in a mixture of 60% dimethylsulfoxide (DMSO) and 40% water as well as 9% aqueous solution of sodium benzoate were both effective. Human
214433 NADH-cytochrome c reductase, a component of benzoate 1,2-dioxygenase system, was purified to homogeneity, as judged by sodium dodecyl sulfate disc gel electrophoresis and ultracentrifugation, from benzoate-induced cells of Pseudomonas arvilla. unknown
77900 A single method for the quantitative determinations of three active ingredients, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and brompheniramine maleate, and one inactive ingredient (sodium benzoate) in a commercial product for colds is reported. Unknown
11416 Potassium sorbate, sodium benzoate, sulfur dioxide, and diethylpyrocarbonate (DEPC) were tested for their effectiveness in preventing the outgrowth of Byssochlamys nivea Westling ascospores. Ascomycota
Saccharomycetales
11416 Growth was observed in grape juice containing 1000 ppm sodium benzoate. unknown
11416 The time elapsed between heat shock and exposure to DEPC or sodium benzoate is critical with respect to the sensitivity of ascospores to these preservatives. unknown
7456349 Sodium caffeine-benzoate at concentrations 6 x 10(-6) M and 6 x 10(-5) M increased the rate of free oxidation of succinic acid in myocardial mitochondria suggesting possibility of uncoupling of respiration and oxidative phosphorylation. Dogs
7202483 The effects of sodium salicylate, sodium benzoate and 5-bromo salicylate on nerve fibres of the rabbit cervical vagus and of the frog sciatic nerve 'in vitro' were studied and using the single sucrose gap technique. Rabbits
7202483 Sodium salicylate was 3--5 times less potent than 5-bromo salicylate; while sodium benzoate was practically ineffective in producing the phenomena under study. unknown
7207259 The purpose of this work was to study the conditions for the reaction of co-oxidation of pyridine by seven strains of Pseudomonas using succinic acid, glucose, and sodium salicylate and benzoate as a growth substrate. Unknown
7220583 Experiments have been performed to optimize the composition of tablets with 250 mg of noramidopyrine methanesulphonate sodium, 250 mg of aminophenazone and 100 mg of caffeine + sodium benzoate. Unknown
7223750 Acacia and sodium benzoate were present in the suspension, the final concentration of which was 25 mg/ml disulfiram. Unknown
7293241 Aniline as well as sodium benzoate, though not metabolized by strain H, cause a concentration-dependent inhibition of phenol degradation in resting phenol-grown cells of that strain. unknown
7062313 The CL response was decreased by inhibitors that prevent particle uptake (iodoacetate and fluoride), inhibitors that prevent free-radical production (sodium benzoate and superoxide dismutase), and by inhibitors that inactivate myeloperoxidase (cyanide and azide). Human
7071828 Effects of ortho-iodo-sodium benzoate (OISB) on oxygen-hemoglobin affinity and its relation to plasma concentrations in dogs. Dogs
7071828 Effects of ortho-iodo-sodium benzoate (OISB) on oxygen-hemoglobin affinity were studied in unanesthetized beagles with simultaneous measurement of its plasma concentrations. unknown
7094940 Potentiation of hyperammonemia by sodium benzoate in animals. A note of caution. Mice
7116748 Glycine encephalopathy in a neonate. Treatment with intravenous strychnine and sodium benzoate. Human
7169669 No evident carcinogenicity was found in medaka treated with 2-fluorenylamine, 2-fluorenylacetamide, DL-ethionine, luteoskyrin, ochratoxin A, phenobarbital, 1-(2-tetrahydrofuryl)-5-fluorouracil, sodium benzoate, 2,3,4,5,6-penta-O-acetyl-D-gluconyl isothiocyanate, citrinin and fusarenon X, respectively, although toxic lesions or hyperplastic changes were demonstrated histologically. unknown
7186696 The effects of oestradiol benzoate or of experimentally induced infection on the absorption of sodium benzylpenicillin from the uterus were investigated in three groups of clinically normal, non-pregnant, Friesian cows. Cattle
7186696 Oestradiol benzoate in oil was administered either into the uterus or intramuscularly one hour before the infusion of 22,000 iu/kg of sodium benzylpenicillin. unknown
7049238 The hydroxyl free radical scavenger sodium benzoate (100 mM) was found to inhibit 99% and 25% of DNA breakage and cross-linking activities, respectively, suggesting DNA breakage and cross-linking may be independently mediated. unknown
6638013 Sodium phenolate and sodium salts of benzoic acid, 2,4-DNP, phenylpropionic acid, and salicylic acid were also inhibitory. unknown
6694345 A therapeutic trial with additional sodium benzoate did not show a positive effect. Human
6476124 A newly synthesized prostaglandin analogue, 4-3-[3-[2-(1-hydroxycyclohexyl)- ethyl]-4-oxo-2-thiazolidinyl]propyl benzoic acid, increases renal blood flow without increasing sodium excretion. unknown
6482716 The infection of the sodium benzoate or potassium gluconate into the disinfecting chloramine solution and sterilizing hydrogene peroxide solution has been shown to improve the resistance to the corrosion for medical instruments made of carbon steel. Unknown
6486381 Treatment with a low-protein diet and sodium benzoate resulted in a normalized blood ammonia level, but her plasma citrulline levels remained unchanged. unknown
6497901 Addition of GSH or free-radical scavengers (catalase, superoxide dismutase, mannitol, sodium benzoate or L-histidine) prevented the effect of nifurtimox on lipid peroxidation reactions. unknown
6508078 The eleven strains studied were prototrophic and did not grow in media containing only 1% Bacto-peptone or Bacto-tryptone; they grew rapidly in media containing 0.4% yeast extract and 0.2% sodium acetate or benzoate. Bacillus
6523500 We studied the effect of ortho-iodo sodium benzoate (OISB) given intraperitoneally to mice. Mice
6221686 Positive reactions were seen mostly with formaldehyde (4.7 p. 100), Bronopol (4.7 p. 100), ammoniated mercury chloride (3.8 p. 100), benzoic acid (2.1 p. 100), sodium benzoate (1.9 p. 100), parabens (1.9 p. 100), dichlorophen (1.7 p. 100), chloracetamid (1.5 p. 100), benzyl benzoate (1.5 p. 100), Germall 115 (1.2 p. 100), butylhydroxyanisol (1 p. 100) and Dowicil (0.8 p. 100). Human
6457813 As shown by agarose gel electrophoresis analyses, the nicking reaction is (i) oxygen-dependent, (ii) strongly inhibited by catalase and an electron scavenger such as cystamine, and (iii) totally suppressed by ceruloplasmin and radical scavengers such as t-butanol sodium benzoate. Unknown
6265438 Second, in direct relation to their effectiveness as .OH scavengers, thiourea, dimethyl thiourea, sodium benzoate, and dimethyl sulfoxide inhibited H2O2-mediated killing of S. aureus. unknown
6317542 Of the scavengers of toxic oxygen metabolites tested only the hydroxyl radical scavenger sodium benzoate inhibited cytotoxicity. unknown
6325341 On the other hand, scavengers of singlet oxygen and OH (sodium benzoate, histidine) did not affect the synergistic LDCL responses induced by these multiple ligands. unknown
6311259 DMPO-OH production was inhibited from these systems by catalase and sodium benzoate whereas superoxide dismutase gave a small increase in the rate of DMPO-OH production. unknown
6311259 Addition of catalase and sodium benzoate decreased the production of DMPO-OH only. unknown
6153872 The effect of food colors and sodium benzoate on rat peritoneal mast cells. Rats
6155392 The same agents reported to exacerbate chronic urticaria, i.e., indomethacin, mefenamic acid, sodium salicylate, aspirin, sodium benzoate, and tartrazine, also augmented allergic histamine release. unknown
6083770 AHG-induced CL was not inhibited by superoxide dismutase, catalase or 2,5-dimethyl furan, but was suppressed in the presence of phenol, sodium benzoate, sodium formate and mannitol. Human
6195239 Re-use of disposable haemodialysers, cleaned and disinfected with sodium hypochlorite and benzoic acid, was evaluated bacteriologically and clinically during the course of 514 dialysis treatments, performed with 206 RP6 dialysers used up to three times. Bacteria
Human
7406487 Comparison of anti-Vibrio activities of potassium sorbate, sodium benzoate, and glycerol and sucrose esters of fatty acids. Vibrio parahaemolyticus
7406487 The effects of fatty acids and their glycerol and sucrose esters, potassium sorbate, and sodium benzoate on growth of Vibrio parahaemolyticus in laboratory media at pH 6.7 were evaluated. unknown
7406487 Potassium sorbate and sodium benzoate inhibited growth at concentrations as low as 30 and 300 microgram/ml, respectively, and enhanced the rate of thermal inactivation of V. parahaemolyticus at slightly higher concentrations. unknown
7406487 Fatty acid esters of glycerol and sucrose offer potential as perservatives for slightly acid or alkaline low-fat foods which do not lend themselves to the full antimicrobial action of traditional food preservatives such as potassium sorbate and sodium benzoate. unknown
7189717 DNA and its precursors might interact with the food preservatives, sodium sulphite and sodium benzoate. Cattle
7189717 The interaction of sodium sulphite and sodium benzoate with nucleosides and DNA has been studied in vitro. unknown
7195189 The combined and independent effects of sucrose, sodium chloride, potassium sorbate, and sodium benzoate on heat inactivation of conidia of Aspergillus flavus and Penicillium puberulum, ascospores of Byssochlamys nivea, and vegetative cells of Geotrichum candidum were studied. Ascomycota
Mitosporic Fungi
Saccharomycetales
7195189 Potassium sorbate and sodium benzoate acted synergistically with heat to inactivate all four molds. unknown
7195189 At the same concentration, potassium sorbate was clearly more inhibitory than was sodium benzoate to colony formation by A. flavus, and the presence of sucrose and sodium chloride enhanced this inhibition. unknown
6264089 The results indicated that the administration of glycine receptor antagonist (strychnine) together with a low-protein diet (1.5 gm/kg/day), augmentation of 1-C units (N(5)-formlytetrahydrofolate), and removal of glycine from extracellular fluid (sodium salicylate and sodium benzoate) yielded some clinical improvement and positive biochemical changes in out patients. Human
6799751 Benzoic acid, sodium benzoate, ethyl-rho-aminobenzoate and omicron-hydroxybenzoic acid (salicylic acid) have been found to inhibit mycelial growth and aflatoxin production by A. flavus in groundnut. Aspergillus flavus
6799751 Benzoic acid (10 mg/g) completely inhibited both mycelial growth and aflatoxin production while sodium benzoate achieved the same result at 24 mg/g of medium. unknown
7078580 These pathways involve synthesis and excretion of hippurate after sodium benzoate administration, and of citrulline and argininosuccinate after arginine supplementation. unknown
7108765 To determine if glycine and urea metabolism are changed during administration of benzoate to patients with chronic renal failure, 10 g/day of sodium benzoate was given to seven patients with an average estimated glomerular filtration rate of 8 ml/min. unknown
7144780 Cytogenetic effects of the food preservatives--sodium benzoate and sodium sulphite on Vicia faba root meristems. Legumes
7144780 Sodium sulphite and sodium benzoate induce in Vicia faba root meristems: (1) dose-dependent reduction in mitotic figures, (2) intact and severed anaphase bridges, (3) premature chromosome condensation heading to pycnotic nuclei, and (4) chromatin erosion in interphase nuclei. unknown
6299514 It has been found that with careful choice of conditions (suitable concentration of the protective agent, pretreatment of cells) substantial protective effect of alpha-tocopherol, sodium benzoate, acetylsalicylic acid, catalase, peroxidase or superoxide dismutase can be achieved. unknown
6295125 After undergoing exhaustive studies (including case histories, cutaneous tests for reactions to food antigen, peripheral eosinophils, secretory and humoral immunity, determination of total IgE and of specific RAST, exclusion-provocation diets) and without being able to identify an offender, patients were submitted to oral provocation with different food additives (tartrazine, sunset yellow FCF, new coccine, erythrosine, sodium benzoate, 4-methyl hydroxybenzoate and acetylsalicylic acid) after 48 hours of exclusion from their diets of dyes, preservatives and salicylates. Human
6758697 Salmonella typhimurium ATCC 7136 exhibited major changes in lipid composition when grown in the presence of either 0.15% sodium deoxycholate or 0.15% sodium benzoate. Salmonella typhimurium
6796778 Evidence of lack of toxicity of sodium phenylacetate and sodium benzoate in treating urea cycle enzymopathies. Human
6825366 Effect of long-term administration of sodium benzoate to a patient with partial ornithine carbamoyl transferase deficiency. Human
6825366 An 8-year-old girl with partial ornithine carbamoyl transferase deficiency was treated with sodium benzoate (200 mg/kg/day) for 13 months. unknown
6825366 Before administration of sodium benzoate, her protein intake was reduced to 1.0 to 1.5 g/kg/day and her caloric intake fluctuated. unknown
6825366 After the start of administration of sodium benzoate, the severity and frequency of these attacks decreased, although her protein intake was increased to 1.5 to 2.0 g/kg/day. unknown
6825366 No adverse effect of sodium benzoate were detected by clinical and laboratory examinations. unknown
6825366 It is concluded that long-term oral administration of sodium benzoate was effective in reducing the frequency and severity of hyperammonemic attacks in this patient. unknown
6825366 Sodium benzoate therapy in combination with dietary manipulation may improve the growth and development of these patients by allowing reduced dietary protein restriction. unknown
6826919 High-performance liquid chromatographic determination of sodium benzoate when used as a tracer to detect pulpwash adulteration of orange juice. Unknown
6842341 Disposition of sodium benzoate in newborn infants with hyperammonemia. Human
6842341 Sodium benzoate lowers serum ammonia concentrations by the activation of a non-urea cycle pathway of ammonia removal. unknown
6842341 The disposition of sodium benzoate was monitored in four hyperammonemic newborn infants, using a simple and newly developed assay for benzoate and hippurate, to assess (1) the metabolic capability of patients of this age to utilize this pathway for nitrogen removal, (2) the potential risks of benzoate toxicity at clinically achieved serum benzoate concentrations, and (3) the value of routine monitoring of serum benzoate concentrations in this patient population. unknown
6842341 Although sodium benzoate offers considerable promise for the treatment of hyperammonemia, toxicity appears likely in some infants receiving this drug in currently recommended doses. unknown
6886925 Treatment of hyperammonemia with sodium benzoate. Human
6623463 We investigated levels of the glycine cleavage system in livers of spf-fur mutant mice with ornithine transcarbamylase (OTC) deficiency treated with sodium benzoate. unknown
6465866 Therapy with a low-protein diet, lactulose, and sodium benzoate has prevented recurrence of hyperammonemia and symptoms. unknown
6128108 Denaturation kinetic studies of the hemoglobin with sodium benzoate was performed and the results were compared with that of Rana catesbeiana, i.e. the pseudo-first order of the hemoglobin denaturation reaction are low for the aquatic P. pipae adult although for the B. paracnemis high molecular resistant was also noted. unknown
6137530 The permeation of barbitone sodium, benzoic acid, and salicylic acid from microcapsules into aqueous medium has been examined at different pH values. Unknown
6125108 Anaphylactoid reaction to general anaesthesia: a case of intolerance to sodium benzoate. Human
6626604 The effects of sodium benzoate, ascorbic acid and cystein on the kinetics of oxidation of oxyhemoglobin in the presence of sodium nitrite were studied. Cattle
6626604 It was shown that sodium benzoate and ascorbic acid suppress nitrite methemoglobin formation more intensively than cystein. unknown
6626604 Possible mechanisms underlying the inhibiting effects of sodium benzoate, ascorbic acid and cystein are discussed. unknown
6427608 To treat such episodes, we designed a therapeutic protocol that included prompt recognition of hyperammonemia, therapy with intravenous sodium benzoate, sodium phenylacetate, and arginine, and nitrogen-free intravenous alimentation. Human
3987717 In this infant the blood concentration of ammonia could not be lowered below 1000 micrograms/dl using peritoneal dialysis, while treatment with sodium benzoate led to control within 24 h. Human
3995654 The administration of equitoxic dosages of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK) and p-(3,3-dimethyl-1-triazeno)sulfonic acid sodium salt (DM-SO3Na) 1 h after carrageenin application, causes 4 h later a similar and statistically significant reduction of paw swelling by about 40% whereas, p-alanylphenyl-3,3-dimethyl-1-triazeno (DM-ALA(OH)) is inactive. Guinea Pigs
4044762 Nitrate and monofluorophosphate are extracted from the dentifrice with deionized water and separated by a low capacity anion separator column with 0.2% sodium benzoate (adjusted to pH 5.8 +/- 0.1 with formic acid) as the mobile phase. unknown
4044762 Nitrate and monofluorophosphate are extracted from the dentifrice with deionized water and separated by a low capacity anion separator column with 0.2% sodium benzoate (adjusted to pH 5.8 +/- 0.1 with formic acid) as the mobile phase. unknown
3902331 The meglumine, sodium, or combined meglumine-sodium salts of triiodinated benzoic acid derivatives, diatrizoic and iothalamic acid, are commonly used as intravascular ionic contrast media for radiographic visualization of blood vessels and the urinary tract. Human
3761164 On the other hand, the hydrotropic salts, sodium benzoate, sodium salicylate, and sodium gentisate, are shown to be the best water solubilizers in 1-butanol. unknown
3761164 The effect of sodium benzoate, sodium salicylate, and sodium lauryl sulfate on the solubility of water in 1-hexanol was also investigated. unknown
3777926 LES-MF holding medium contains tryptone, m-Endo broth, dipotassium hydrogen phosphate, sodium benzoate, sulfanilamide, para-aminobenzoic acid, and cycloheximide (pH 7.0). m-ST holding medium contains ethanol, sodium monophosphate, dipotassium hydrogen phosphate, sulfanilamide, and Tris (pH 8.6). Enterobacteriaceae
3804536 Peak responses to both stimuli were dose-dependently inhibited in a similar manner by p-hydroxymercuribenzoate (10(-5) - 10(-3) mol/l), sodium benzoate (10(-5) - 10(-3) mol/l.) and quinacrine (10(-6) - 10(-3) mol/l.). Guinea Pigs
Propionibacterium acnes
3590176 The patient has been treated with the restriction of protein intake, oral administration of an essential amino acid mixture, and sodium benzoate or phenylacetic acid. Human
3601478 Renal hemodynamics and functions were assessed in four groups of anaesthetized newborn rabbits receiving a single intravenous dose of methylxanthines, i.e.: aminophylline: 3 mg/kg (A1) or 6 mg/kg (A2); sodium benzoate caffeine: 5 mg/kg (C1) or 10 mg/kg (C2). Rabbits
3433275 Plasma and cerebrospinal fluid (CSF) concentrations and urinary excretion of guanidino compounds were investigated in a patient with hyperargininemia during the treatment with low-protein diet, oral administration of an essential amino acid mixture and sodium benzoate, or enzyme replacement therapy such as exchange transfusion or erythrocyte transfusion. Human
3444390 Reaction of 3-bromo-2-methoxymethylpropyl benzoate with the sodium salt of hexadecanethiol leads to 3-hexadecylmercapto-2-methoxy-methylpropanol, which is reacted with a cyclic chlorophosphate to give the corresponding phosphorylated 3-hexadecylmercapto-2-methoxymethylpropanol. unknown
3446058 250 mg/kg/d of sodium benzoate were given. Human
3500167 Sodium benzoate was not an attractant but was a competitive inhibitor of the propionate uptake system. Unknown
3508233 Sodium benzoate was borderline in its effect on the blood ammonia and on orotic acid excretion. unknown
3508674 She continued to have profound neurologic impairment and seizures and died at 26 months of age, despite appropriate dietary protein restriction, sodium benzoate, and arginine supplementation. Human
3366174 Inhibitory effects of some cyclohexylaralkylamines related to perhexiline on sodium influx, binding of [3H]batrachotoxinin A 20-alpha-benzoate and [3H]nitrendipine and on guinea pig left atria contractions. Guinea Pigs
Rats
3380863 Nifedipine (1), a drug practically insoluble in water, has been solubilized employing sodium benzoate (2) and sodium salicylate (3) as hydrotropes. Unknown
3381713 The provocations with the rest of the NSAI and tartrazine and sodium benzoate were negative in all of the patients. Human
3413212 Sodium benzoate (2; 30% w/v) and sodium salicylate (3; 30% w/v) have been employed as the vehicle to prepare the injection of 1 in 1 mg/5 ml and 1 mg/2 ml concentration in either case. Rats
3419873 Despite the treatment based on hypoprotidic diet, sodium benzoate and arginine, the child presented several hyperammoniemic comas. Human
3408801 2-Hydroxyethyl methacrylate (HEMA) monomer and sodium benzoate, diluted with saline in the range 0-20%, were tested for intradermal irritation in rats. Rats
2907327 Moreover, enhancement of transglutaminase activity by treatment of macrophages with SRBC or IgG-coated SRBC was partially suppressed by sodium benzoate, which is a scavenger of hydroxy radical. unknown
2912297 Postpartum seizure after epidural blood patch and intravenous caffeine sodium benzoate. Human
2918401 Ureagenesis was inhibited by sodium benzoate in hepatocytes from lean livers, but not in hepatocytes from fatty livers. unknown
2918401 Incorporation of [14C]NaHCO3 into orotate was also inhibited by sodium benzoate, but in hepatocytes from fatty as well as lean livers. unknown
2930092 INTERVENTIONS: Maximal exercise treadmill testing and exercise echocardiography were done at baseline, after acute ingestion of a placebo beverage (97% caffeine-free coffee), or after drinking an identical beverage containing 250 mg of caffeine sodium benzoate. Human
2703687 We report a case of post-lumbar-puncture headache successfully treated with intravenous caffeine sodium benzoate. Human
2703687 Caffeine sodium benzoate (500 mg) in 1 liter of fluid (D5LR) intravenously over one and a half hours was administered. unknown
2703687 Caffeine sodium benzoate is a simple treatment of post-lumbar-puncture headaches. unknown
2708272 A rapid, simple, and reliable liquid chromatographic method has been developed for the simultaneous determination of nicotinamide (niacinamide), thiamine, riboflavin, riboflavin sodium phosphate, pyridoxine, caffeine, and sodium benzoate in commercial oral liquid tonics. unknown
2715254 A high-performance liquid chromatographic method for the quantitation of the mucoactive drug sodium 2-(3-thiazolidinylcarbonyl)benzoate in plasma and urine was developed, involving liquid-liquid extraction under acidic conditions and reversed-phase chromatography using ultraviolet detection at 210 or 235 nm. Human
3598771 Nevertheless, continued therapy with sodium benzoate, arginine-HCl, carnitine and lactulose did not have any observable effect on the blood concentration of ammonia. Human
2839175 Lipid peroxidation was significantly inhibited by superoxide dismutase, but not by catalase or sodium benzoate. unknown
2462910 In contrast, all of these metabolic transformations are strongly inhibited by pretreatment of the rats with sodium benzoate, an inhibitor of D-amino acid oxidase. unknown
2462910 In vivo 2H NMR studies of sodium benzoate treated rats given L-[methyl-2H3]-methionine exhibit a much more rapid formation of [methyl-2H3]sarcosine than rats given the D enantiomer, consistent with the expectation that the sodium benzoate does not interfere with either the formation of S-adenosylmethionine or the subsequent transmethylation of glycine. unknown
2462910 However, the rates of methionine clearance and formation of deuteriated water are markedly reduced in this study relative to rats receiving the labeled D- or L-methionine without sodium benzoate pretreatment. unknown
2313932 Scavengers of the microsomal lipid peroxidation induced by CER, (+)-cyanidanol-3, mannitol, sodium benzoate and N-acetyl tryptophan, which are scavengers of hydroxyl free radicals, inhibited the CER-stimulated lipid peroxidation in the microsomes. unknown
2390669 CD-1 mice receiving single intraperitoneal doses of caffeine-sodium benzoate solution (caffeine doses: 0, 20, and 40 mg kg-1) were evaluated in an activity monitor, and their plasma and brain caffeine and metabolite concentrations were determined by high performance liquid chromatography (h.p.l.c.). Mice
2182567 A simple, innocuous, yet underutilized form of treatment is caffeine sodium benzoate. Human
2252765 Hemoperfusion was then initiated with or without (control) the solutizer (sodium benzoate). Dogs
2252765 The bilirubin unbinding effect of sodium benzoate was rapid and effective. unknown
2252765 Because of the simultaneous adsorption of sodium benzoate, a small activated carbon section that was presaturated with the solutizer was located proximal to the main hemoperfusion column, in addition to continuous infusion to reach 20 mM in the blood. unknown
2252765 Sodium benzoate may also have the advantage of protecting platelets during hemoperfusion. unknown
2253246 Pyridoxine, magnesium, neutral phosphate and sodium benzoate were used to prevent deposition of oxalate in the transplanted kidney. unknown
2272564 The rate of lipid peroxidation by photosensitized benzanthrone was inhibited by 64-80% with 1,4-diazabicyclo(2,2,2)octane and sodium azide, 15% with superoxide dismutase but was not affected by mannitol and sodium benzoate. unknown
2125819 Either alpha-tocopherol or desferrioxamine completely abolished the dopa-Fe3+ complex-induced phospholipid peroxidation, while superoxide dismutase, catalase, or sodium benzoate did not. unknown
2167493 CD-1 mice received single intraperitoneal (IP) doses of caffeine-sodium benzoate (caffeine doses: 0, 20 and 40 mg/kg) followed by injections of alprazolampropylene glycol (0, 0.05, and 2 mg/kg, IP) to determine brain concentrations, effects on in vivo receptor binding of a specific high-affinity benzodiazepine receptor ligand [3H]Ro15-1788, and effects on motor activity over a 1-h period. unknown
1998941 Studies employing various quenchers of reactive oxygen species revealed that scavengers of singlet oxygen (histidine, 2,5-dimethylfuran, beta-carotene and sodium azide) afforded substantial protection (up to 90%) of photoenhancement whereas the scavengers of hydrogen peroxide (catalase), superoxide anion (superoxide dismutase), and hydroxyl radical (sodium benzoate, mannitol and ethanol) were ineffective in this regard. unknown
2012137 Treatments, including a protein-restricted diet, arginine supplementation, and sodium benzoate administration, resulted in a favorable prognosis for survivors with partial enzyme deficiency. unknown
2069426 In vitro addition of scavengers of the superoxide anion (O2-.) radical and hydrogen peroxide (H2O2) such as superoxide dismutase (SOD) and catalase, respectively, prevented argemone oil augmented microsomal lipid peroxidation to a lesser extent as compared to the scavengers of singlet oxygen (1O2) such as 2,5-dimethylfuran (DMF), beta-carotene, and histidine or hydroxyl (OH.) radical scavengers such as ethanol, mannitol and sodium benzoate. unknown
1858805 Solutions of methadone were prepared in (1) orange-flavored Tang, (2) grape-flavored Kool-Aid, (3) apple juice, (4) grape-flavored Crystal Light, and (5) grape-flavored Crystal Light plus 0.1% sodium benzoate. Unknown
1858805 Only three Crystal Light plus sodium benzoate solutions were prepared at the same methadone concentrations and stored at 20-25 degrees C for up to 29 days. unknown
1858805 Methadone was stable (loss of potency, less than 5%) for up to 17, 11, 9, and 8 days when stored at 20-25 degrees C in Kool-Aid, Tang, apple juice, and Crystal Light, respectively, and for up to 29 days when stored at 20-25 degrees C in Crystal Light plus sodium benzoate. unknown
1858805 All the solutions that did not contain sodium benzoate and were stored at room temperature displayed unacceptable microbial growth after approximately two weeks. unknown
1896509 The present experiment characterized the hamster's taste reactivity to an array of stimuli (sugars: 1 M sucrose, d-fructose and d-glucose; sodium salts: 1 M NaCl, Na2SO4 and NaNO3; acids: 30 mM HCl, tartaric acid and citric acid; bitter-tasting stimuli: 100 mM quinine hydrochloride and nicotine sulfate and 10 mM denatonium benzoate). Hamsters
1758445 DNA cleavages were significantly inhibited in the presence of hydroxyl radical scavengers, such as sodium benzoate and dimethylurea, in the Cu(2+)-SA and Fe(3+)-PD systems, with or without UV irradiation. unknown
1815268 It was also found that by adding 20% glycerol and 1% sodium benzoate, cultures were stable at 20 degrees C for 30 days. unknown
1816329 Rat livers were perfused with [15N]glycine and unlabeled sodium benzoate by the single-pass technique via the portal vein or in retrograde fashion via the inferior vena cava. unknown
1651226 Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Mice
1662314 However, three of four hydroxyl radical scavengers used (mannitol, dimethyl sulfoxide, sodium benzoate) did not significantly decrease cell death. unknown
1842043 They induce DNA strand break at low concentration upon photoirradiation which are inhibited in the presence of hydroxyl radical scavengers such as mannitol or sodium benzoate. Escherichia coli
1727686 Although antioxidants (deferoxamine and sodium benzoate) have been reported to protect against pure aminoglycoside nephrotoxicity, they did not mitigate gentamicin's adverse impact on postischemic acute renal failure. unknown
1540370 Grand mal seizure in a postpartum patient following intravenous infusion of caffeine sodium benzoate to treat persistent headache. Human
1540370 A presumptive diagnosis of an occult postdural puncture headache (PDPH) was made, and the patient was treated with an intravenous (IV) infusion of 500 mg of caffeine sodium benzoate (CSB) to vasoconstrict dilated cerebral vessels. unknown
1547989 After a short remission following treatment by protein restriction and oral administration of sodium benzoate, she had disturbed consciousness due to exaggerated hyperammonemia and died of severe brain edema. unknown
1599605 Acute doses of caffeine-sodium benzoate (0, 20, 40, and 60 mg/kg, intraperitoneally [0, 0.10, 0.21, 0.31 mu mol/kg]) were given to CD-1 mice and their activity was measured in an animal activity monitor over a 1-hour period. Mice
1599892 Similarly, the use of blood patch or intravenous caffeine sodium benzoate to treat the headache did not differ significantly between groups. unknown
1414689 The 8OHdG formation decreased after addition of hydroxyl radical scavengers (sodium benzoate, dimethylsulfoxide, and mannitol) and increased after addition of platelet-activating factor (PAF), an agent known to stimulate the generation of reactive oxygen metabolites in neutrophils. unknown
1429919 The final formulation contained sweetening agents (sucrose, saccharin sodium), flavours (cherry, sweet), a desensitizing agent (menthol), a dye (FD&C Red #40) and a preservative (benzoic acid) to incorporate the desired organoleptic and preservative properties. unknown
1494304 The in vitro penetration of theophylline, sodium diclofenac and benzoic acid through artificial cellulose membrane and eight animal skins was investigated. Human
Mice
Rana catesbeiana
Rats
Swine
1287147 In the Rec-assay, salicylic acid (2 mg), aspirin (5 mg), benzoic acid (4 mg), sulpyrine (0.4 mg), indomethacin (0.1 mg), oxyphenbutazone (0.1 mg) and diclofenac sodium (0.1 mg) showed a DNA-damaging tendency. Bacillus subtilis
Guinea Pigs
Hamsters
Mice
Rats
Salmonella typhimurium
1312851 Addition of hydroxyl radical scavengers such as catalase, dimethyl sulfoxide, 1,3 dimethyl-2-thiourea (DMTU), sodium benzoate, and mannitol prevented the radical generation. unknown
1334455 In the present study, LTG was found to block sustained repetitive firing of sodium-dependent action potentials in mouse spinal cord cultured neurons and inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding in rat brain synaptosomes suggesting a direct interaction with voltage-activated sodium channels. unknown
2036013 Cultures supplemented with 100 mM sodium acetate took up [14C]acetate and [14C]benzoate in accordance with the Henderson-Hasselbalch equation and gave similar estimates of intracellular pH. unknown
2176186 Sodium azide, the myeloperoxidase inhibitor, and sodium benzoate produced a similar potentiating effect. unknown
2311875 Neither superoxide dismutase, catalase, nor sodium benzoate offered any protection against ethanol-induced injury, indicating that neither superoxide anion, hydrogen peroxide, nor the hydroxyl radical is involved. unknown
2155965 Incubation of activated macrophages with catalase, catalase and superoxide dismutase, sodium benzoate with or without catalase, and respiratory burst-exhausting PMA failed to inhibit the killing of T. cruzi in vitro. unknown
2329467 The influence of pH on rectal absorption of sodium benzoate studied in man by rectal lumen perfusion. Human
2329467 The influence of pH on rectal absorption of sodium benzoate in man was studied by means of a rectal lumen perfusion method and compared with in vitro measurements on diffusional transport of sodium benzoate across an octanol/water interface. unknown
2346672 Plasma and urinary levels of carnitine in different experimental models of hyperammonemia and the effect of sodium benzoate treatment. Mice
2346672 The effect of sodium benzoate on plasma carnitine levels, during both an acute and a prolonged treatment, consisted in a significant lowering of free carnitine and a significant increase in the acyl/free carnitine ratio, in both +/Y normal and spf/Y mouse models. unknown
8474200 Addition of sodium benzoate 0.1% reduced survival to less than 7 days. Escherichia coli
Human
8474200 Risk of transmission can be reduced by washing and brushing apples before pressing, and preserving cider with sodium benzoate. unknown
8375432 Either alpha-tocopherol or desferrioxamine completely abolished the dopa-Fe3+ complex-induced phospholipid peroxidation, while SOD, catalase or sodium benzoate did not. unknown
8255899 Other animals, primed with EB and 200 micrograms progesterone, showed a facilitation of sexual receptivity after infusion into the VTA of 50 micrograms sodium valproate, a GABAA transaminase inhibitor. Hamsters
8283967 Administration of antioxidants such as reduced glutathione or sodium benzoate prior to stress causes significant decrease in ulcer index and lipid peroxidation and protection of gastric peroxidase activity suggesting the involvement of reactive oxygen species in stress induced gastric ulceration. unknown
8285854 The DNA cleavage by BHT-quinone was inhibited by oxygen radical scavengers including superoxide dismutase (SOD), catalase, polyethylene glycol, t-butyl alcohol, dimethyl sulfoxide, sodium azide, sodium benzoate, bovine serum albumin and methionine, while it was enhanced by the addition of FeCl2. unknown
8286958 Recently, the combination of sodium or potassium benzoate with ascorbic acid was shown to produce low levels (ng/g) of benzene in fruit-flavored soft drinks. Unknown
8286958 Slightly higher levels were present in some foods and beverages containing both ascorbic acid and sodium benzoate. unknown
7682684 Of the eight preservatives used, sodium benzoate and methylparabens were present in 42 and 27 of the preparations, respectively. unknown
7904403 To identify possible phototoxic properties, 13 food additives (benzoic acid, sodium benzoate, 4-hydroxybenzoic acid, 4-hydroxybenzoic acid methyl ester, 4-hydroxybenzoic ethyl ester, 4-hydroxybenzoic acid propyl ester, p-hydroxybenzoic acid n-butyl ester, benzyl alcohol, sorbic acid, potassium sorbate, propionic acid, sodium disulfite and sodium sulfite) were evaluated in vitro by means of a photohemolysis test using suspensions of human erythrocytes. Human
8419623 We gradually reduced the doses and then discontinued treatment with sodium benzoate and phenylacetate; blood glutamine levels were maintained in the normal range, but ammonia was mildly elevated. Human
8419623 Some patients with citrullinemia can be successfully managed without daily sodium benzoate and phenylacetate therapy. unknown
8424807 Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia. Mice
8424807 We studied the effect of sodium benzoate (2.5, 5 and 10 mmol/kg body wt) on ammonia, glutamine and glutamate, as well as various intermediates of energy metabolism in brain and liver of normal CD-1/Y and hyperammonemic spf/Y mice. unknown
8424807 The ammonia concentration of brain was decreased with 2.5 mmol sodium benzoate in spf/Y mice, whereas higher doses resulted in a significant increase in both liver and brain. unknown
8424807 Cerebral glutamine content decreased generally in a dose-dependent manner, both in normal and affected mice, following treatment with various doses of sodium benzoate. unknown
8424807 Cerebral glutamate concentrations were increased only in spf mice treated with sodium benzoate, whereas ATP and acetyl CoA were decreased (P < 0.001), in both normal and affected mice, indicating that glutamine synthesis may be affected by ATP availability. unknown
8424807 Free CoA levels were decreased (P < 0.05) only in liver in both groups of treated mice, whereas pyruvate concentrations were elevated (P < 0.05) in affected mice following sodium benzoate administration. unknown
8424807 The response of the spf/Y mouse to sodium benzoate was different from that of the control CD-1/Y mouse, which could be due to its urea cycle dysfunction and a chronic hyperammonemic state. unknown
8424807 Hence, the spf/Y mouse may be the ideal animal model for studying the pharmacology of sodium benzoate in hyperammonemic disorders at both the cerebral and hepatic levels. unknown
8381329 In addition to SA, a number of structurally related compounds including dihydroxybenzoic acids, aspirin, and sodium benzoate also enhanced MC540-mediated cell killing. Human
8322155 In 16 patients with PTBD because of obstructive jaundice and 11 patients without hepatic disease, 1.77 grams of sodium benzoate was injected and the amount of hippurate synthesized and excreted in the urine collected at 30, 60, 120 and 180 minutes was measured (hippurate test). Human
8102193 L-Carnitine supplementation to spf/Y mice during sodium benzoate therapy also restored the availability of free CoA and ATP, thus counteracting the adverse effects of higher doses of sodium benzoate. unknown
8368839 In addition, the efficacy of two preservatives, 0.1% sodium benzoate and 0.1% potassium sorbate, used separately and in combination was evaluated for antimicrobial effects on the bacterium. Escherichia coli
Human
8368839 In contrast, survivors in cider containing sodium benzoate were detected for only 2 to 10 days or less than 1 to 2 days at 8 or 25 degrees C, respectively. unknown
8368839 The highest rates of inactivation occurred in the presence of a combination of 0.1% sodium benzoate and 0.1% potassium sorbate. unknown
8368839 The use of 0.1% sodium benzoate, an approved preservative used by some cider processors, will substantially increase the safety of apple cider in terms of E. coli O157:H7, in addition to suppressing the growth of yeasts and molds. unknown
8212059 Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice. Mice
Rats
8212059 F344 rats and B6C3F1 mice of each sex were administered 0, 1.81, 2.09 or 2.40% (for rats) and 0, 2.08, 2.50 or 3.00% (for mice) of sodium benzoate in the diet for 10 days. unknown
8217412 Branched chain amino acids transfusion was effective for consciousness disturbance, and sodium benzoate was effective for hyperammonemia. unknown
8242478 The object of this study was to measure carnitine levels in skeletal muscles of experimental mice with acute, subacute, and chronic hyperammonemia, with or without sodium benzoate treatment. Mice
8242478 A decrease in free and esterified levels of carnitine in the muscles was observed among normal mice treated with sodium benzoate. unknown
8242478 A decrease in esterified carnitine was also noticed among spf mice given an acute treatment with sodium benzoate as well as among normal and spf mice given a prolonged treatment with sodium benzoate. unknown
8242478 However, the levels in spf mice treated with sodium benzoate were not significantly different from those in untreated spf controls in which a significant increase in plasma creatine kinase was already caused by chronic hyperammonemia.(ABSTRACT TRUNCATED AT 250 WORDS) unknown
8295092 Effect of a sodium benzoate-sodium bicarbonate compound on dental plaque formation. Human
8295092 The objective of this study was to evaluate the effect of a sodium benzoate-sodium bicarbonate (SBSB) compound on dental plaque formation and developing gingivitis. unknown
8105054 Comparison of depolarizing and direct current systems on iontophoretic enhancement of transport of sodium benzoate through human and hairless rat skin. Human
Rats
8105054 A direct current (DC) system and a pulsed depolarization (PD) system were evaluated for their iontophoretic permeation of sodium benzoate, as a model drug, through hairless rat and human skin. unknown
8105054 Approximately the same initial permeation of sodium benzoate through the hairless rat skin was obtained at 0.1 mA for the DC device and at 3.0 mA for the PD device. unknown
8221447 Intravenous caffeine sodium benzoate therapy effectively relieves PDPH, but the headache may recur. Human
4383683 The effects of the administration of sodium benzoate and diethylstilbestrol disulfate on the nepatic levels of several glucocorticoid-sensitive enzymes in adrenalectomized rats. Rats
4379567 Tyrosine-alpha-ketoglutarate transaminase. Effect of the administration of sodium benzoate and related compounds on the hepatic enzyme level. Rats
8206871 Pretreatment of the membranes with diphenylamine effectively prevented the ascorbic acid/Fe2+/t-BuOOH-induced decreases in the DACM-labeling and DPH incorporation rates, whereas neither superoxide dismutase, catalase, sodium benzoate, nor mannitol showed a protective effect. unknown
8048060 The in vitro study has been extended using structurally unrelated, pharmacologically relevant compounds including ethanol, glycerol, cyclohexanol, acetone, benzoic acid, phenol, acrylamide, triethanolamine, Tween 80, sodium dodecyl sulfate, benzalkonium chloride, NiSO4, SnCl2, and ZnCl2. Human
7834261 A patient receiving electroconvulsive therapy (ECT), clozapine, and intravenous caffeine sodium benzoate developed supraventricular tachycardia. Human
8012969 Acetylsalicylic acid, 2,3- and 2,5-dihydroxybenzoic acids, and sodium benzoate also enhance MC540 uptake. Human
Mice
8034782 This study evaluated the desorption of radiolabelled albumin from synthetic hydroxypatite by 4 commercial prebrushing solutions: Lysoplac (containing chlorhexidine), Plax (sodium benzoate), Acti-Brush (triclosan), and Sanogyl (sodium fluoride). Human
8074967 The effect of selected antimicrobials (potassium sorbate, sodium benzoate and sodium lactate) on the growth and survival of Salmonella in milk and in cheese at various storage temperatures was also examined. Enterococcus faecalis
Salmonella
Salmonella typhimurium
8074967 Addition of sodium benzoate (0.3%) to cheese (pH 6.6) or addition of potassium sorbate (0.3%) to cheese (pH 6.0) made from milk, which was acidified to pH 5.9 with propionic acid, had a significant impact on delaying or preventing growth of the pathogen. unknown
8165914 Response to sodium benzoate treatment in non-ketotic hyperglycinaemia. Human
8165914 No toxicity of sodium benzoate treatment was detected when administering doses of up to 470 mg/kg BM per day but side effects such as itching and hyperactivity were obvious. unknown
7728964 The formation of 8OHdG by PHQ was reduced by oxygen radical scavengers such as catalase, sodium benzoate and sodium azide. Cattle
7732609 Oral sodium benzoate and folic acid therapy was initiated. Human
7788574 When asymptomatic, the patients were subjected to a double-blind oral challenge, under placebo control, with additives (monosodium glutamate, tartrazine, sulfites, erythrosine, paraoxybenzoate, sodium benzoate, lactose, aspirin, and annate), which was again negative. Human
7548755 The effect of cytosol was inhibited by potassium cyanide but not by sodium benzoate or dimethyl sulfoxide, and was also not affected by heating at 60 degrees C for 30 min, suggesting that superoxide (SO) ion was involved in the reaction and that it was blocked by superoxide dismutase (SOD) present in the cytosol. unknown
8548487 The system generating the light signal contained luminol and compounds producing enhancement of light emission, such as sodium benzoate and indophenol. Rats
7699832 She suffered a consciousness disturbance due to hyperammonemia, which was successfully treated by oral administration of sodium benzoate before surgery. unknown
7699832 Although the serum ammonia level temporarily increased during a postoperative interruption of oral administration of sodium benzoate, the patient did not develop loss of consciousness, which is a key sign of hyperammonemia. unknown
7762664 This latter transport system was functionally characterized by 1) inhibition of cellular cholate uptake in the absence of extracellular sodium by the dicarboxylic acid alpha-ketoglutarate (alpha-KG; 1 mM) and by the organic anion p-aminohippurate (PAH; 1 mM); 2) stimulation of cellular cholate uptake by alpha-KG (10 microM) or PAH (1 mM) in the presence of an inwardly directed sodium gradient; 3) lack of sensitivity toward lithium in BLPM vesicles; 4) trans-stimulation of vesicular cholate uptake by alpha-KG or PAH, but not by benzoate; and 5) cis-inhibition of alpha-KG/alpha-KG self-exchange by extravesicular cholate (400 microM), PAH (5 mM), probenecid, or DIDS. unknown
7558184 Rats inhaling a mixture of N2O:O2 (1:1) for 5 hr showed inactivation of MS in liver to nearly 90% which could not be reversed by prior administration of either dimethyl sulfoxide (DMSO) or sodium benzoate. unknown
7574591 The addition of sodium acetate, but not that of sodium chloride, affected the threshold value; higher acetate concentrations resulted in higher threshold values for benzoate. unknown
8521779 The results reveal (i) a decrease of variability, together with an increase in degradation rate of the tested chemicals due to a better control of inoculum and test medium, and (ii) no difference in easy biodegradable compound (sodium benzoate) biodegradation rate when two marine aquarium inocula are tested. Unknown
8523191 DESIGN: Patients for this study included 24 infants born before 1990 and rescued from hyperammonemic coma caused by neonatal-onset ASD; they were referred to this center for enrollment in ongoing clinical studies of sodium benzoate, sodium phenylacetate, and sodium phenylbutyrate. unknown
8527331 Raw chicken wings inoculated with Salmonella, Campylobacter jejuni, Listeria monocytogenes, Staphylococcus aureus, or Escherichia coli O157:H7 were washed in water (control) or a solution of a 0.5% lactic acid/0.05% sodium benzoate (LB) (pH 2.64) for 30 min. Bacteria
Campylobacter jejuni
Chickens
Escherichia coli
Salmonella
8527331 Washing chicken wings with a solution containing 0.5% lactic acid and 0.05% sodium benzoate can greatly reduce the populations of pathogenic and psychotrophic bacteria, thus enhancing safety and extending shelf life. unknown
8952792 Oral challenges with bisulfite and sodium benzoate, both additives abundantly ingested by the patient, revealed heightened sensitivity to administration of sodium benzoate. Human
8935777 The order of photoprotection of the five potential photostabilizers were as follows: sodium thiosulfate > EDTA > sodium benzoate approximately thiourea > sodium metabisulfite. unknown
8760263 Hydroxyl radical scavengers, dimethylthiourea, salicylate, and sodium benzoate, and two metal chelators, deferoxamine and 1,10-phenanthroline, also provided marked protection against DNA strand breaks and DNA fragmentation. unknown
8657542 We report the case of a 1-year-old infant with NKH, seizure disorder, and psychomotor delay who was clinically seizure free during treatment with sodium benzoate, arginine, benzodiazepam, and phenobarbital. unknown
8657542 Although sodium benzoate normalized serum glycine levels (103 to 125 mumol/L), cerebrospinal fluid glycine levels remained elevated (42 to 47 mumol/L), with epileptiform activity on electroencephalography. unknown
8706142 Analysis of in vitro iontophoretic skin permeation of sodium benzoate by transport numbers of drug and additives. Rats
8706142 One cell facing the stratum corneum was filled with sodium benzoate solution, and the other cell facing the dermis with lithium chloride (LiCl), potassium chloride (KCl) or tetraethylammonium bromide (TEA-Br) solution. unknown
8706142 Iontophoretic delivery rate of benzoate anion that permeated through skin increased with an increase in the sodium benzoate concentration while maintaining a constant KCl concentration. unknown
8706142 In contrast, a flux of benzoate anion decreased with an increase in KCl concentration and a constant concentration of sodium benzoate. unknown
8778603 The patients were assigned to treatment that consisted of sodium benzoate, alone or in combination with sodium phenylacetate or sodium phenylbutyrate, or sodium phenylbutyrate alone. unknown
8746443 Lipophilic antioxidants BHA, BHT, and alpha-tocopherol were about 20 times more effective than hydrophilic free radical scavengers sodium benzoate, inositol, DMSO, and mannitol in preventing LOOH-induced strand breaks, supporting lipid phase localization of the damage. unknown
9149811 The usefulness of this approach for predictive testing of the preservatives MI/MCI, imidazolidinyl urea, methyl-4-hydroxy-benzoate and 2-phenoxyethanol in comparison to the strong allergen DNFB and the irritants sodium lauryl sulphate and dithranol was explored. Human
9346466 Therapy continues to rely on alternative substrate administration including sodium benzoate and sodium phenylacetate. unknown
2155661 Catalase (20 micrograms/ml) and 10 mM sodium-benzoate did not affect the iron-glycated polylysine-induced lipid peroxidation, indicating no participation of an OH. in this reaction. unknown
2173015 Ultrasound-induced production of MDA could not be inhibited to any significant degree by superoxide dismutase, histidine, dimethylfuran, or beta-carotene but was very significantly inhibited by cholesterol (93%), butylated hydroxytoluene (88%), alpha-tocopherol (85%), sodium benzoate (80%), dimethyl sulfoxide (80%), sodium formate (64%), and EDTA (64%). unknown
8112377 Effect of single oral dose of sodium benzoate on ureagenesis in healthy men and two patients with late onset citrullinaemia. Human
8112377 Although sodium benzoate therapy is beneficial in patients with inborn error of urea cycle, it has been suggested that an accumulation of benzoyl-CoA would inhibit ureagenesis. unknown
8112377 In this study, we examined several aspects of ureagenesis after the single oral dosing of sodium benzoate in six healthy subjects who participated in the study previously reported and in two patients with citrullinaemia. unknown
8112377 Urea nitrogen appearance (UNA) did not change after the doses of 40, 80 and 160 mg.kg-1 of sodium benzoate in the 6 healthy subjects. unknown
8112377 In the 2 patients with late-onset citrullinaemia who benefit from a partially functional urea cycle, no apparent inhibitory effects on the UNA were observed after the administration of 80 mg/kg of sodium benzoate. unknown
8127924 Detoxification of sodium benzoate by elimination as a conjugate with glycine, a nonessential amino acid, provides a pathway for the disposal of waste nitrogen. unknown
8127924 Since 1979, sodium benzoate has been widely used in the therapeutic regimen to combat ammonia toxicity in patients born with genetic defects in the urea cycle. unknown
8210064 Sodium benzoate is conjugated with glycine in the liver and the kidney, which may cause the elimination of one mole of alpha-amino N for each mole of benzoate administered. Mice
8210064 The object of this study was to identify the secondary effects of acute sodium benzoate treatment on the concentrations of carnitine in liver and muscle when the glycine availability in these tissues is still assured. unknown
8210064 The animals were given 2.5, 5.0 and 10.0 mmol/kg sodium benzoate intraperitoneally. unknown
8210064 Our results demonstrate that sodium benzoate influences the homeostasis of liver and muscle carnitine after only 15 minutes of treatment. unknown
8210064 The carnitine concentrations in each tissue differ depending on the dose of sodium benzoate administered, which may suggest a biphasic effect. unknown
8210064 Our results indicate that sodium benzoate has a secondary effect on the liver and muscle concentration of carnitine from the beginning of its intramitochondrial metabolism.(ABSTRACT TRUNCATED AT 250 WORDS) unknown
8466802 The effect of temperature, pH, sodium chloride concentration and a preservative (sodium benzoate, sodium nitrite or potassium sorbate) on the growth of three foodborne bacterial pathogens (Bacillus cereus, Vero cytotoxigenic Escherichia coli and Staphylococcus aureus) was studied using gradient gel plates. unknown
8489027 The urinary excretion of [2,4,6,7-13C4]HA formed from intravenously administered [2,4,6,7-13C4]BA was followed by proton-decoupled 13C NMR spectroscopy (only 10 min accumulation time) without any separation procedures such as extraction and chromatography, using [2-13C]sodium acetate as an internal standard for quantitation. unknown
8517351 This new technique may be useful to control the effect of a sodium benzoate therapy by monitoring the cerebral glycine concentration directly. Human
8264193 The authors studied experimentally the morphological changes of injuries and the surrounding areas after a skin chemical injury caused by sodium hydroxide, sulphuric acid and chlorhydric acid under the influence of acidic necrolytics--40% benzoic acid and 40% salycilic acid in unguentus. Unknown
8292744 Sodium benzoate reduced the cytotoxicity of DCTH, indicating a role for coenzyme A in the bioactivation of DCTH. unknown
989656 Next in order is sodium benzoate, then oxalate. unknown
8012969 Acetylsalicylic acid, 2,3- and 2,5-dihydroxybenzoic acids, and sodium benzoate also enhance MC540 uptake. Human
Mice
8034782 This study evaluated the desorption of radiolabelled albumin from synthetic hydroxypatite by 4 commercial prebrushing solutions: Lysoplac (containing chlorhexidine), Plax (sodium benzoate), Acti-Brush (triclosan), and Sanogyl (sodium fluoride). Human
8074967 The effect of selected antimicrobials (potassium sorbate, sodium benzoate and sodium lactate) on the growth and survival of Salmonella in milk and in cheese at various storage temperatures was also examined. Enterococcus faecalis
Salmonella
Salmonella typhimurium
8074967 Addition of sodium benzoate (0.3%) to cheese (pH 6.6) or addition of potassium sorbate (0.3%) to cheese (pH 6.0) made from milk, which was acidified to pH 5.9 with propionic acid, had a significant impact on delaying or preventing growth of the pathogen. unknown
8165914 Response to sodium benzoate treatment in non-ketotic hyperglycinaemia. Human
8165914 No toxicity of sodium benzoate treatment was detected when administering doses of up to 470 mg/kg BM per day but side effects such as itching and hyperactivity were obvious. unknown
7847413 Compatibility of 10% sodium benzoate plus 10% sodium phenylacetate with various flavored vehicles. Human
7885541 Failure of early dextromethorphan and sodium benzoate therapy in an infant with nonketotic hyperglycinemia. Human
7885541 We report an infant with neonatal nonketotic hyperglycinemia (NKH), diagnosed early and treated with dextromethorphan (DM) and sodium benzoate therapy from the 65th hour of life. unknown
7885541 In spite of increasing doses of DM as high as 40 mg/kg/day and persistent therapy with sodium benzoate the child progressively deteriorated and died at the age of 5 months and 7 days. unknown
7885541 We stress that the adverse clinical course occurred in our patient even though DM and sodium benzoate therapy was started much earlier than in other reported cases. unknown
7887143 Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study. Actinobacillus actinomycetemcomitans
Bacteria
Candida albicans
Gram-Positive Cocci
Human
Porphyromonas gingivalis
7887143 The minimum inhibitory concentrations (MICs) of sodium benzoate and dichlorobenzyl alcohol to 115 strains of plaque microorganisms were determined by a broth-dilution method. unknown
7887143 Sodium benzoate did not inhibit growth of any gram-positive cocci (MIC > 106,590 microM). unknown
7887143 Saliva samples from 10 volunteers, collected at various times after toothbrushing with a dentifrice containing 10% sodium benzoate and 0.3% dichlorobenzyl alcohol, were analyzed gas-chromatographically. unknown
7887143 Immediately after toothbrushing mean levels of sodium benzoate and dichlorobenzyl alcohol were 372,626 microM and 7,529 microM, respectively. unknown
7699242 Sodium benzoate and lactulose for the treatment of hepatic encephalopathy. Rats
7705289 SOD, catalase, and sodium benzoate inhibited lipid peroxidation by 49, 52, and 75%, respectively, again showing the role of oxygen radicals in silica-induced lipid peroxidation.(ABSTRACT TRUNCATED AT 250 WORDS) unknown
7591853 Levels of sodium benzoate in processed food from the Philippines and Japan were analyzed by high performance liquid chromatography. Human
7591853 The samples with sodium benzoate included 19 juice, 6 softdrink and 6 soy sauce varieties. unknown
7591853 As for the Japanese products, only 8 (26%) out of 31 food items tested positive for sodium benzoate. unknown
7728964 The formation of 8OHdG by PHQ was reduced by oxygen radical scavengers such as catalase, sodium benzoate and sodium azide. Cattle
7732609 Oral sodium benzoate and folic acid therapy was initiated. Human
7788574 When asymptomatic, the patients were subjected to a double-blind oral challenge, under placebo control, with additives (monosodium glutamate, tartrazine, sulfites, erythrosine, paraoxybenzoate, sodium benzoate, lactose, aspirin, and annate), which was again negative. Human
7654514 The effect of selected antimicrobials (potassium sorbate, sodium benzoate, and sodium lactate) added to milk or cheese on the growth and survival of these pathogens at various storage temperatures was also evaluated. Escherichia coli
7654514 Addition of sodium benzoate (0.3%) to cheese (pH 6.6) or addition of potassium sorbate (0.3%) to cheese (pH 6) made from milk acidified to pH 5.9 with propionic acid, had a significant impact on delaying or preventing growth of the pathogens. unknown
7661457 Pharmacokinetic variables of caffeine were studied in 6 adult lactating dairy cows after i.v. administration of a single dose of caffeine sodium benzoate (2 mg of caffeine/kg of body weight). Cattle
7548755 The effect of cytosol was inhibited by potassium cyanide but not by sodium benzoate or dimethyl sulfoxide, and was also not affected by heating at 60 degrees C for 30 min, suggesting that superoxide (SO) ion was involved in the reaction and that it was blocked by superoxide dismutase (SOD) present in the cytosol. unknown
7574726 Four hydroxyl radical scavengers, namely mannitol, dimethyl sulfoxide, sodium benzoate, and Trolox, were tested for their ability to protect DNA from oxidative damage by peroxynitrite. unknown
8548487 The system generating the light signal contained luminol and compounds producing enhancement of light emission, such as sodium benzoate and indophenol. Rats
8582405 Her standard therapy with arginine hydrochloride (4 mmol/kg/day) and sodium benzoate (200 mg/kg/day) was continued. unknown
7568622 In addition, ibogaine interacted with N-methyl-D-aspartic acid (NMDA) associated ion and sodium ion channels as determined by the inhibition of [3H]MK-801 and [3H]bactrachotoxin A 20-alpha-benzoate binding (BTX-B), respectively. unknown
8745268 In the OVX rat implanted with a silastic tube packed with estradiol-benzoate (E2) for 1 day, MUA volleys were unclear, mingled with high background activities, but clear volleys appeared after PB injection. Rats
8745268 No PB effect was seen in the LH pulse amplitude in the E2-implanted OVX rat. unknown
7699832 She suffered a consciousness disturbance due to hyperammonemia, which was successfully treated by oral administration of sodium benzoate before surgery. unknown
7699832 Although the serum ammonia level temporarily increased during a postoperative interruption of oral administration of sodium benzoate, the patient did not develop loss of consciousness, which is a key sign of hyperammonemia. unknown
7762664 This latter transport system was functionally characterized by 1) inhibition of cellular cholate uptake in the absence of extracellular sodium by the dicarboxylic acid alpha-ketoglutarate (alpha-KG; 1 mM) and by the organic anion p-aminohippurate (PAH; 1 mM); 2) stimulation of cellular cholate uptake by alpha-KG (10 microM) or PAH (1 mM) in the presence of an inwardly directed sodium gradient; 3) lack of sensitivity toward lithium in BLPM vesicles; 4) trans-stimulation of vesicular cholate uptake by alpha-KG or PAH, but not by benzoate; and 5) cis-inhibition of alpha-KG/alpha-KG self-exchange by extravesicular cholate (400 microM), PAH (5 mM), probenecid, or DIDS. unknown
7558184 Rats inhaling a mixture of N2O:O2 (1:1) for 5 hr showed inactivation of MS in liver to nearly 90% which could not be reversed by prior administration of either dimethyl sulfoxide (DMSO) or sodium benzoate. unknown
7574591 The addition of sodium acetate, but not that of sodium chloride, affected the threshold value; higher acetate concentrations resulted in higher threshold values for benzoate. unknown
8521779 The results reveal (i) a decrease of variability, together with an increase in degradation rate of the tested chemicals due to a better control of inoculum and test medium, and (ii) no difference in easy biodegradable compound (sodium benzoate) biodegradation rate when two marine aquarium inocula are tested. Unknown
8523191 DESIGN: Patients for this study included 24 infants born before 1990 and rescued from hyperammonemic coma caused by neonatal-onset ASD; they were referred to this center for enrollment in ongoing clinical studies of sodium benzoate, sodium phenylacetate, and sodium phenylbutyrate. unknown
8527331 Raw chicken wings inoculated with Salmonella, Campylobacter jejuni, Listeria monocytogenes, Staphylococcus aureus, or Escherichia coli O157:H7 were washed in water (control) or a solution of a 0.5% lactic acid/0.05% sodium benzoate (LB) (pH 2.64) for 30 min. Bacteria
Campylobacter jejuni
Chickens
Escherichia coli
Salmonella
8527331 Washing chicken wings with a solution containing 0.5% lactic acid and 0.05% sodium benzoate can greatly reduce the populations of pathogenic and psychotrophic bacteria, thus enhancing safety and extending shelf life. unknown
8562862 Tissue acylcarnitine and acyl-coenzyme A profiles in chronically hyperammonemic mice treated with sodium benzoate and supplementary L-carnitine. Mice
8562862 The aim of the present study, was to establish the hepatic profile of acyl-coenzyme A (acyl-CoA) in relation to the hepatic profile of acylcarnitines in chronically hyperammonemic spf mice (hereditary deficiency in ornithine transcarbamylase) treated with sodium benzoate alone or in combination with L-carnitine. unknown
8562862 Following administration of sodium benzoate, we observed decreases in hepatic total and free coenzyme A and in acetyl-CoA, which was accompanied by an increase in hepatic acyl-CoA. unknown
8562862 In mice receiving a combination of sodium benzoate and L-carnitine, increases in free and total coenzyme A, acetyl-CoA and in free, total and esterified hepatic carnitines were observed. unknown
8562862 Our results indicate that sodium benzoate is implicated in the decrease of total hepatic coenzyme A, through either an inhibition of CoA synthesis or activation of its degradation. unknown
8562862 The distribution of hepatic coenzyme-A and of hepatic and muscular carnitine (free or esterified) is altered following administration of sodium benzoate which results in a further destabilization of the sarcolemma induced by hyperammonemia. unknown
8562862 Supplemental treatment with L-carnitine was shown to have a positive effect by increasing hepatic coenzyme A and carnitine levels and restoring the stability of the sarcolemma caused by the treatment of sodium benzoate alone. unknown
8581365 Free and esterified coenzyme A in the liver and muscles of chronically hyperammonemic mice treated with sodium benzoate. Mice
8581365 Ammonia toxicity and relative sodium benzoate toxicity alters the energy metabolism, leading to a decrease of adenosine triphosphate and free coenzyme A levels. unknown
8581365 The object of the present study was to analyze the hepatic and muscular acyl-coenzyme A profiles in chronically hyperammonemic mice treated with varying doses of the sodium benzoate. unknown
8581365 Treatment with sodium benzoate at moderate doses, caused a decrease in the hepatic free and esterified coenzyme A while these were increased at higher doses. unknown
8581365 The sodium benzoate had a biphasic effect on the hepatic content of free and esterified coenzyme A, suggesting a degradation of coenzyme A at moderate doses. unknown
8585564 Five patients presenting with non-ketotic hyperglycinemia in the neonatal period were treated with sodium benzoate to normalize plasma glycine levels. unknown
9338090 Rat liver homogenates were subjected to oxidative stress with sodium perborate, and the light signals, generated by a suitable system, containing luminol and compounds producing enhancement of light emission such as sodium benzoate and indophenol, were detected by a luminometer. Rats
8752493 5) Some patients with AIA are hypersensitive to some agents in addition to NSAID, e.g., tartrazine (15.1%), sodium benzoate (14.3%), and parabens (12.0%). unknown
8645340 However, the inhibitory activity could not be attributed to the known stable oxidation product of anthralin, danthron, which did not decrease (12-LO activity. Addition of the antioxidants 2,6-di-tert-butyl-4-methylphenol (BHT) or beta-carotene, or the hydroxyl radical scavenger sodium benzoate, protected against anthralin-mediated 12-LO inactivation, suggesting that pro-oxidant species derived from anthralin play a key role in the inhibitory action. unknown
8696779 Glutathione, thiourea, EDTA, sodium thiosulfate, sodium metabisulfite, glycine, sodium benzoate and uric acid were found to be ineffective as photoprotective agents. Unknown
8952792 Oral challenges with bisulfite and sodium benzoate, both additives abundantly ingested by the patient, revealed heightened sensitivity to administration of sodium benzoate. Human
8935777 The order of photoprotection of the five potential photostabilizers were as follows: sodium thiosulfate > EDTA > sodium benzoate approximately thiourea > sodium metabisulfite. unknown
8962508 The CZE method was used to determine the content of paeonol, oxypaeoniflorin, benzoic acid, pentagalloylglucose and gallic acid, and MEKC technique based on sodium cholate was applied to analyze albiflorin, paeoniflorin, benzoyla biflorin, paeonol and oxypaeoniflorin. Unknown
8960159 This effect was strongly enhanced by CuCl2 and suppressed by EDTA, bathocuproinedisulfonic acid disodium salt, methionine, glutathione reduced form or catalase, but was not affected by mannitol, sodium benzoate or sodium azide. unknown
8760263 Hydroxyl radical scavengers, dimethylthiourea, salicylate, and sodium benzoate, and two metal chelators, deferoxamine and 1,10-phenanthroline, also provided marked protection against DNA strand breaks and DNA fragmentation. unknown
8657542 We report the case of a 1-year-old infant with NKH, seizure disorder, and psychomotor delay who was clinically seizure free during treatment with sodium benzoate, arginine, benzodiazepam, and phenobarbital. unknown
8657542 Although sodium benzoate normalized serum glycine levels (103 to 125 mumol/L), cerebrospinal fluid glycine levels remained elevated (42 to 47 mumol/L), with epileptiform activity on electroencephalography. unknown
8706142 Analysis of in vitro iontophoretic skin permeation of sodium benzoate by transport numbers of drug and additives. Rats
8706142 One cell facing the stratum corneum was filled with sodium benzoate solution, and the other cell facing the dermis with lithium chloride (LiCl), potassium chloride (KCl) or tetraethylammonium bromide (TEA-Br) solution. unknown
8706142 Iontophoretic delivery rate of benzoate anion that permeated through skin increased with an increase in the sodium benzoate concentration while maintaining a constant KCl concentration. unknown
8706142 In contrast, a flux of benzoate anion decreased with an increase in KCl concentration and a constant concentration of sodium benzoate. unknown
8778603 The patients were assigned to treatment that consisted of sodium benzoate, alone or in combination with sodium phenylacetate or sodium phenylbutyrate, or sodium phenylbutyrate alone. unknown
8746443 Lipophilic antioxidants BHA, BHT, and alpha-tocopherol were about 20 times more effective than hydrophilic free radical scavengers sodium benzoate, inositol, DMSO, and mannitol in preventing LOOH-induced strand breaks, supporting lipid phase localization of the damage. unknown
8862025 Spores were heated in distilled water, Sorensen buffer (0.18 mol 1-1), McIlvaine buffer (0.0025-0.18 mol 1-1), and several solutions containing sodium chloride (0.06-12%), sodium nitrite (125 ppm), potassium sorbate (0.1%) and sodium benzoate (0.1%) over a wide range of temperatures (115-140 degrees C). Bacillus stearothermophilus
8901073 The integral heat of adsorption of water vapor on sodium benzoate samples was determined at various partial vapor pressures using a heat conduction microcalorimeter. Unknown
8901073 The model satisfactorily described the experimental calorimetric data of water vapor adsorption on sodium benzoate. unknown
8812724 Chronic sodium benzoate therapy in children with inborn errors of urea synthesis: effect on carnitine metabolism and ammonia nitrogen removal. Human
8812724 Sodium benzoate (SB) therapy is known to increase ammonia (NH3) nitrogen elimination via conjugation with glycine and excretion as urinary hippurate. unknown
8930703 A study was undertaken to determine the efficacy of yeast malt extract agar (YMA), acidified YMA (YMAA), acidified tryptone glucose yeast extract agar (TGYA) and Zygosaccharomyces bailii agar (ZBA) for enumerating two strains of Z. bailii (FRR 2227 and FRR 3680) grown and heated in blueberry syrup containing 0, 300 and 600 micrograms/ml sodium benzoate. Saccharomycetales
8930703 Regardless of the sodium benzoate concentration in growth and heating media, or the temperature and time of heating, non-selective YMA supported recovery of the highest number of viable cells, followed by TGYA for strain FRR 2227 and TGYA or ZBA for strain FRR 3680. unknown
8930703 The concentration of sodium benzoate in the growth medium did not have a significant effect on tolerance of strain FRR 3680 to heat; however, tolerance of strain FRR 2227 to heat decreased when cells were grown in blueberry syrup containing increased concentrations of sodium benzoate. unknown
8930703 Regardless of the sodium benzoate concentration in the growth medium, both strains exhibited increased sensitivity when heated in blueberry syrup containing increased concentrations of sodium benzoate. unknown
8896961 Perioral contact urticaria from sodium benzoate in a toothpaste. Human
9012770 The inactivation effect, as measured by survival determination, was abolished by thiourea, sodium benzoate, dipyridyl or catalase. unknown
8888048 Postnatal clinical presentation and initial cerebrospinal fluid and plasma glycine levels were not predictive of outcome, but early treatment with N-methyl-D-aspartate modulators appeared to reduce late neurological complications and probably is as important as treatment with sodium benzoate. unknown
8930680 The effects of a mouthrinse containing sodium benzoate and alcohol on the quantity and metabolism of dental plaque. Human
8930680 The aim of this study was to investigate the efficacy of a pre-brushing rinse containing sodium benzoate and alcohol, on 2 week old dental plaque. unknown
8930680 Thus, a single oral rinse with a mouthrinse containing sodium benzoate and alcohol does not affect removal of plaque nor does it seems to influence the glycolytic potential of the plaque. unknown
9072517 Fresh catfish (Clarias gariepinus) were subjected to different concentrations of sodium benzoate or potasium sorbate and smoked traditionally before evaluation for microbiological, chemical and organoleptic characteristics during ambient tropical storage. Catfish
Enterobacteriaceae
Gram-Positive Bacteria
Mitosporic Fungi
9138311 The effectiveness of two commonly used preservatives, sodium benzoate and potassium disulfite, was evaluated in terms of their bactericidal activity and capacity to induce changes in the surface properties of Escherichia coli isolated from commercial food preserves. Escherichia coli
Rats
9384745 These baseline perturbations are observed in a simple CE system that does not employ sample injection and with sodium benzoate as the running electrolyte. Unknown
9552339 Pharmaceutical excipients such as ethanol, glycerin, propylene glycol, methylparaben, propylparaben, artificial strawberry flavor, and sodium benzoate did not show any adverse effect on the activity of BDG-GO-CAT. unknown
9033181 Administration of sodium benzoate and sodium phenylacetate lowered the serum ammonia level effectively in both cases. unknown
9149811 The usefulness of this approach for predictive testing of the preservatives MI/MCI, imidazolidinyl urea, methyl-4-hydroxy-benzoate and 2-phenoxyethanol in comparison to the strong allergen DNFB and the irritants sodium lauryl sulphate and dithranol was explored. Human
9160106 Sodium propionate (PA-Na) and sodium benzoate (BA-Na) had little effect on any cytotoxic parameter in either group of cells. unknown
9200893 The enamel surface conditions were: 1. no conditioning; 2. salicylic acid (10%, 10s); 3. benzoic acid (10%, 10s); 4. air polishing with sodium hydrogen carbonate/Prophy-Jet; 5. Cattle
9181696 When sperm were treated with three plasma membrane-permeable SH-depleting reagents, N-ethyl-maleimide, sodium tetrathionate and 5,5'-dithiobis (2-nitro-benzoic acid), the rates of cleavage of eggs were significantly lower than those with control sperm. Mice
9346466 Therapy continues to rely on alternative substrate administration including sodium benzoate and sodium phenylacetate. unknown
8143859 SOD significantly suppressed this lipid peroxidation, while catalase or sodium benzoate did not. unknown
9098874 The metabolic inhibitors, sodium azide and 2,4-dinitrophenol, significantly inhibited the uptake of [14C]benzoic acid by ROEpi. Rabbits
9169011 Thiourea is extremely effective as a protective agent, dimethyl sulfoxide is moderately effective, while sodium benzoate and mannitol are slightly effective. Unknown
9332465 The changes in DOX resulting from UVA irradiation in the presence of riboflavin, were not blocked by 1,4-diazabicyclo [2.2.2]octane (5 mM), superoxide dismutase (300 units/ml), catalase (150 units/ml) or sodium benzoate (50 mM). unknown
9351212 A sodium benzoate-sorbic acid preservative system of a pharmaceutical product was proved effective against a wild strain of Pseudomonas cepacia, following the official method of the Italian and British Pharmacopoeias. Burkholderia cepacia
9361202 Resistance of yeast flora of labaneh to potassium sorbate and sodium benzoate. Candida
Yeasts
9361202 Ten yeast cultures belonging to eight species representing the yeast flora of labaneh were tested for their resistance to potassium sorbate and sodium benzoate. unknown
9361202 Changes in counts were monitored after 7, 14, and 21 d at 5 degrees C in yeast-free labaneh containing different concentrations of potassium sorbate or sodium benzoate. unknown
9361202 More than 400 mg/kg of sodium benzoate were needed to limit the counts of Saccharomyces cerevisiae (biovariants 1, 2, and 7) Cryptococcus curvatus, Pichia farinosa, Candida blankii, Debaryomyces hansenii, and Trichosporon brassicae to < or = 10(5) cfu/g after 14 d at 5 degrees C; 150 and 300 mg/kg were needed for Geotrichum candidum and Trichosporon cutaneum, respectively. unknown
9361202 Less than 150 and < 250 mg/kg of potassium sorbate and sodium benzoate, respectively, were needed to limit yeast counts to < 10(5) cfu/g for 7 d at 5 degrees C in two commercial labaneh samples that had initial yeast counts of 4.8 x 10(2) and 9.0 x 10(2) cfu/g; 200 and > 400 mg/kg were required when the storage was extended to 14 d. unknown
9361202 In commercial labaneh with 9.6 x 10(3) cfu/g, > 300 and > 400 mg/kg of potassium sorbate and sodium benzoate, respectively, were needed to limit the yeast count to < or = 10(5) cfu/g after 7 and 14 d at 5 degrees C. unknown
9347572 The solubility increased up to 63 times in the case of sodium benzoate. unknown
7874062 Improvement of aqueous solubility and rectal absorption of 6-mercaptopurine by addition of sodium benzoate. Rats
7874062 The solubility of 6-mercaptopurine (6-MP) in water increased as the concentration of sodium benzoate or sodium hippurate in the solution increased. unknown
7874062 The solubility of 6-MP in 20% (w/v) sodium benzoate or sodium hippurate solution was about 6-fold larger than that of 6-MP alone. unknown
7874062 The stability constant of the soluble complex of 6-MP with sodium benzoate was estimated to be 2-8 M-1 from (1) phase-solubility study and (2) analysis of chemical shifts observed in 1H-NMR. unknown
7874062 Partition of 6-MP from the saturated solution to n-octanol was also greatly increased by the addition of sodium benzoate or sodium hippurate, the degree being less in the latter. unknown
7874062 Administration of 6-MP with 20% (w/v) sodium benzoate to rat rectum resulted in enhanced absorption and the area under the plasma concentration-time curve was comparable to that obtained by intravenous administration (bioavailability = 100%), while the bioavailability after intrarectal administration of 6-MP with 20% (w/v) sodium hippurate was only 9%. unknown
7562613 Exposure of OHCs to 10 mM sodium benzoate, an amphiphilic anion, reduced resting membrane capacitance at -30 mV by 9.2 +/- 3.2 pF (n = 3). unknown
8833969 The method was used to monitor the stability and measure the half-life of Ro 23-9424 in water and in an L-arginine-sodium benzoate-saline diluent designed to mimic the drug delivery system. unknown
8945749 Sodium benzoate differentially blocks circling induced by D-and L-dopa in the hemi-parkinsonian rat. Rats
8945749 Here we show that sodium benzoate, an inhibitor of D-amino acid oxidase, blocks D-dopa-induced circling while having no effect on circling induced by L-dopa. unknown
8945749 The results suggest that conversion of D-dopa to L-dopa via DHPPA is highly dependent on oxidase activity and that sodium benzoate effectively inhibits this process in vivo in rat. unknown
9223881 We experienced the anesthetic managements of liver transplantations in two OTCD patients, who had been suffering from several episodes of hyperammonemic decompensation despite a restricted protein diet with administration of sodium benzoate. unknown
9402479 Inhibition experiments with the copper chelating agents 1-phenyl-2-thiourea and tropolone, the substrate analogue sodium benzoate and sodium ascorbate support the notion that hemocyte cytotoxic activity is a PO-dependent mechanism. unknown
9491648 Photoinduced lipid peroxidation was measured in the presence of mechanistic probes-deuterium oxide (D2O), sodium azide, superoxide dismutase (SOD), mannitol and sodium benzoate. Human
Mice
Tumor Cells, Cultured
9491648 SOD also inhibited the lipid peroxidation while sodium benzoate and mannitol had no effect. unknown
9614211 The uptake of acetylated low density lipoprotein and the levels of MSR-I mRNA were inhibited by treatment with the oxygen radical scavengers 2,2,6, 6-tetramethylpiperidine-N-oxyl, dimethylthiourea or sodium benzoate, or the iron chelator deferoxamine. unknown
9714304 Our studies point towards the feasibility of an ALCAR treatment in conjunction with other treatment modalities, e.g. sodium benzoate and/or arginine, to improve the availability of cellular ATP and to counteract the effects of hereditary hyperammonemic syndromes in children. unknown
9451687 Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate. Human
9451687 He was treated successfully with the ammonia-trapping agents sodium benzoate and sodium phenylacetate. unknown
9477427 A set of 36 inoculated flasks with 12 controls was stored at 4-5 degrees C and two sets, one protected with 100 mg/l sodium benzoate, were stored at room temperature (25-28 degrees C). Ascomycota
Aspergillus
9477427 Only fruit juices stored at 4-5 degrees C and those containing sodium benzoate stored at room temperature were protected from spoilage by these fungi for 64 days. unknown
9580092 Ethanol and sodium benzoate were incapable of protecting bacterial cells against the lethal interaction. unknown
9620122 The effects of concentration of NaCl (0.5 to 12.5%), methyl paraben (0.0 to 0.2%), sodium propionate (0.3%), sodium benzoate (0.1%), potassium sorbate (0.3%), pH (> 5.9) temperature (4 to 30 degrees C), storage time (up to 58 d) and inoculum (> 10(5) to > 10(-2) per ml) on the log10 probability percentage of one cell of Listeria spp. to initiate growth in a broth system were evaluated in a factorial design study. Listeria monocytogenes
9620122 At pH 5.96 and temperature ranging from 4 to 30 degrees C the concentrations of sodium propionate, potassium sorbate, and sodium benzoate examined allowed growth of L. monocytogenes with lag phases at 4 degrees C of 18, 27 and 21 days, respectively. unknown
9772092 The formation of hydroxyl radicals in the process is suggested by the partial inhibitory effect of 5 mM mannitol and 5 mM sodium benzoate and by the fact that the 1HEt was detected. unknown
9677723 All patients were treated with natural protein restriction, sodium benzoate and arginine administration. Human
9709244 Components of soy sauce such as 10% or 16% NaCl, 5% ethanol, lactic acid, or acetic acid at pH 4.5, sodium benzoate (0.6 g/kg), or p-hydroxybenzoic acid n-butyl ester (0.05 g/liter) caused a reduction of the E. coli O157:H7 population at 30 degrees C, and the anti-E. coli O157:H7 effect of each component was less than that of soy sauce. Escherichia coli O157
Soybeans
9756687 Terbuthylazine, simazine, sodium benzoate, and bromoxynil were adsorbed on highly disperse silicon dioxide powder as an unreactive carrier at a thickness well below one monolayer. Unknown
9756687 Sodium benzoate reacts about a factor of 3 slower. unknown
9778587 Other therapies currently used include ammonia-lowering strategies (using sodium benzoate or sodium phenylacetate) and, in severe cases, liver transplantation. unknown
9798155 Almost similar effects on thermal inactivation of ascospores were noted when potassium sorbate (1/k = 29.38 min) or sodium benzoate (1/k = 27.64 min) or the combination of both (1/k = 27.53 min) was used in mango juice. unknown
9798155 In grape juice, potassium sorbate (1/k = 25.07 min) was more effective than sodium benzoate (1/k = 50.08 min) or the combination of both (1/k = 40.79 min) in inactivation of ascospores of the mold. unknown
9833873 Treatment of oral candidiasis: a study to determine the clinical response of sodium benzoate compared with nystatin suspension. Human
9857711 Dialysis, sodium benzoate, sodium phenylacetate and arginine are used in the treatment of acute hyperammonemia. unknown
9952095 Intravenous administration of caffeine sodium benzoate for postdural puncture headache. Human
9952095 BACKGROUND AND OBJECTIVES: In this study, we evaluated the efficacy and safety of prophylactic administration of intravenous caffeine sodium benzoate for postdural puncture headaches (PDPH) on patients administered spinal anesthesia. unknown
9952095 Patients were randomized by double-blind, placebo-controlled design to receive either 1,000 mL normal saline with 500 mg caffeine sodium benzoate (group C) or 1,000 mL normal saline (group S) during the first 90 minutes after spinal anesthesia administration. unknown
9952095 CONCLUSION: Intravenous caffeine sodium benzoate administration during spinal anesthesia is a simple and safe way to minimize PDPH. unknown
10025724 By the use of a flow cytometric technique a significant increase in p-tyr was demonstrated in LC stimulated in vitro with the strong contact sensitizers TNCB (2,4,6-trinitro-chlorobenzene) and MCI/MI (5-chloro-2-methylisothiazolinone plus 2-methylisothiazolinone) but not after treatment with the irritants sodium lauryl sulphate or benzoic acid. Mice
9694685 Even though the results on large benzoate ions are consistent with the above postulate, much larger citrate ions from sodium and potassium citrate show stabilization at moderate salt concentrations and follow an expected trend of low stability only at large salt concentrations. unknown
10027506 A series of compounds that are detected as "bitter" by humans (caffeine, 1.5x10(-3) M; strychnine, 9x10(-4) M; PTC, 6x10(-5) M, denatonium benzoate, 2.24x10(-4) M; and urea, 3.0x10(-1) M) produced full generalization to the quinine sulfate discriminative stimulus, while "sweet" (sucrose, 2.9x10(-2) M) and "salty" (sodium chloride, 1.4 M) stimuli did not. unknown
10328279 After treatment with sodium benzoate and dextromethorphan, some neurologic improvement was observed, although the glycine levels did not lower. Human
10376715 Sodium benzoate-induced acute leukocytoclastic vasculitis with unusual clinical appearance. Human
10431367 The additive mixture, comprising propyl gallate, octyl gallate, dodecyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, tertiary butylhydroquinone, p-hydroxybenzoic acid methyl ester, p-hydroxybenzoic acid ethyl ester, benzoic acid, sorbic acid, saccharin, aspartame and acesulfame-K, was not resolved using single surfactant micellar systems consisting of sodium dodecyl sulfate (SDS), sodium cholate (SC) or sodium deoxycholate (SDC). Unknown
10456765 Conjugating agents (arginine, sodium benzoate, and sodium phenylacetate) have been added during periods of metabolic decompensation. unknown
9609386 However, sulfate formation from D-cysteine differed from L-cysteine in that it was inhibited by the D-aminoacid oxidase inhibitor sodium benzoate and was not affected by transaminase or gamma-cystathionase inhibitors. unknown
9877431 The rise in cell mortality is completely inhibited by the addition of PO inhibitors sodium benzoate, tropolone and phenylthiourea, and serine protease inhibitors phenylmethylsulfonyl fluoride, benzamidine, N-tosyl-L-phenylalanine chloromethyl ketone and N-tosyl-L-lysine chloromethyl ketone. Urochordata
9877431 In the presence of sodium benzoate and phenylthiourea, there is a significant reduction in the number, size and color intensity of necrotic masses along the contact border of incompatible colonies. unknown
9877431 A significant increase in superoxide anion production, completely inhibited by sodium benzoate, is observed when hemocytes are incubated with heterologous blood plasma. unknown
10490237 On the other hand, none of the classical scavengers of reactive oxygen species (ROS) employed e.g dimethylthiourea, catalase, histidine, mannitol, sodium benzoate, nor the metal chelators desferal and phenanthroline, had any appreciable inhibitory effects on hemolysis induced by DDC + (Cu:Co). unknown
10465044 Methyl methanethiosulfinate was 10 to 100 times more inhibitory against Listeria monocytogenes at pH values of 5, 6, and 7 and was much less influenced by pH than was sodium benzoate. Bacteria
Brassica
Listeria monocytogenes
Yeasts
10545070 METHODS: We compared the effects of the following storage conditions on the stability of these arsenic species: temperature (25, 4, and -20 degrees C), storage time (1, 2, 4, and 8 months), and the use of additives (HCl, sodium azide, benzoic acid, benzyltrimethylammonium chloride, and cetylpyridinium chloride). unknown
10509244 Addition of 1% potassium sorbate or 1% sodium benzoate also decreased survival of L. monocytogenes. unknown
10588568 Prophylactic caffeine sodium benzoate--postdural puncture headache versus caffeine withdrawal headache. Human
10597023 Addition of sodium benzoate partly inhibited the DNA damage, while EDTA completely abolishes DNA-SSB. unknown
10603100 Although this retrospective series is not really representative of the modern treatment combining low protein diet and arginine, sodium benzoate and sodium phenylbutyrate, it is obvious that the long-term outcome of all urea cycle disorders remains very guarded. unknown
10585224 The uptake of benzoic acid by BeWo cells was saturable (K(t) = 0.6 +/- 0.3 mM) at higher concentrations and significantly inhibited by typical metabolic inhibitors, sodium azide and 2, 4-dinitrophenol. unknown
10630571 For the development of mechanistic assays in immunotoxicology, the phenotype, cytokine production, and stimulatory function of dendritic cells (DCs) were assessed after incubation with the chemical haptens aminophenol, chlorpromazine hydrochloride, dinitrochlorobenzene (DNCB), and with the DNCB-corresponding tolerogen DCNB, the metal allergen nickel sulfate, the irritants sodium dodecyl sulfate and benzoic acid, as well as with staphylococcal enterotoxin B (SEB) and lipopolysaccharide (LPS). Human
Staphylococcus aureus
10653488 Sodium benzoate (a preservative added to several seasonings) did not react significantly with ABTS*+, but the sulphite content of certain white wines may have led to an over-estimation of their TEAC. unknown
10682304 Partial response to low-protein diet and sodium benzoate and dramatic response to imipramine are demonstrated, with parental scores on the Developmental Behavioural Checklist falling from the 86th centile before treatment to normal with combined benzoate and imipramine therapy. unknown
10682305 Effect of sodium benzoate in the treatment of atypical nonketotic hyperglycinaemia. Human
10682305 After the patient developed hypsarrhythmia and had a single cerebral seizure, treatment with both sodium benzoate and dextromethorphan was started. unknown
10682305 However, after cessation of sodium benzoate therapy, epileptic activity in the EEG and behavioural changes occurred. unknown
10682305 These changes disappeared promptly after sodium benzoate therapy was reinstituted. unknown
10682305 Thus, this case of mild atypical nonketotic hyperglycinaemia with only moderate psychomotor retardation and without epilepsy benefited from treatment with sodium benzoate in terms of electroencephalographic and behavioural changes. unknown
10682283 The observed correlation occurred irrespective of the substrates investigated (phenol or sodium benzoate), the PHB-producing strain (Ralstonia eutropha JMP 134 or Variovorax paradoxus JMP 116), or the type of limitation imposed. unknown
10567035 Additional experiments carried out on the mechanistic aspects of the genotoxicity of BITC showed that this compound causes formation of thiobarbituric acid-reactive substances in HepG2 cells and that its DNA damaging properties are diminished by alpha-tocopherol, vitamin C, sodium benzoate and beta-carotene, indicating the possible involvement of free radicals in the genotoxicity of BITC. unknown
10690679 Such a complex dissociates under the action of trypsin, PCMB or APMA or sodium dodecyl sulphate. unknown
10678195 Benzoylserine and benzoylthreonine in propionic acidaemia treated with sodium benzoate. Human
10736863 The dynamic ranges of the calibration graphs, obtained by using kinetic and equilibrium measurements, were 0.2-36 micrograms ml-1 and 0.15-30 micrograms ml-1, respectively, for BZ, and 3.3-24 micrograms ml-1 and 4-36 micrograms ml-1 for SC and the detection limits were 0.07 and 0.04 microgram ml-1, respectively, for BZ, and 1.1 and 1.2 micrograms ml-1, respectively, for sodium SC. Unknown
10728803 Prevention and treatment of HE in cirrhotic patients continues to rely on ammonia-lowering strategies which include assessment of dietary protein intake and the use of lactulose, neomycin, sodium benzoate and L-ornithine-aspartate. unknown
10755134 Sodium benzoate, potassium sorbate and sodium propionate, all preservatives commonly used by food industry in Argentina, were tested. Human
10755134 Levels above 10 mg/kg of sodium benzoate and potassium sorbate produced a total inhibition of fungal development and toxin biosynthesis. unknown
10784188 This diet was supplemented with 0 or 3 g/kg of glycine, or with 0, 1.0, 2.07, or 4.15 g/kg of sodium benzoate for mink and blue foxes, and with 0 or 4.5 g/kg of glycine and 0, 1.58, 3.17, or 6.34 g/kg of sodium benzoate for raccoon dogs, respectively. unknown
10784188 In mink, the elimination of ethyl benzoate did not differ from that of sodium benzoate. unknown
10779623 The other oxidant scavengers, such as L-histidine, sodium azide, vitamin E and sodium benzoate, were not found to be effective even up to 1.0 mM concentration. unknown
10801054 Three cases of intravenous sodium benzoate and sodium phenylacetate toxicity occurring in the treatment of acute hyperammonaemia. Human
10801054 Intravenous sodium benzoate and sodium phenylacetate have been used successfully in the treatment of acute hyperammonaemia in patients with urea cycle disorders. unknown
10801054 However, we report three patients with hyperammonaemia who received inappropriate doses of intravenous sodium benzoate and sodium phenylacetate that resulted in severe complications. unknown
10888553 Fresh elder flowers (Sambucus nigra L.) were extracted with an aqueous solution containing sucrose, peeled lemon slices, tartaric acid, and sodium benzoate to make elder flower syrup. Unknown
10955509 A micellar electrokinetic capillary method for the simultaneous determination of the sweeteners dulcin, aspartame, saccharin, and acesulfame-K and the preservatives sorbic acid; benzoic acid; sodium dehydroacetate; and methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutyl-p-hydroxybenzoate in preserved fruits is developed. Unknown
10552679 Influence of pH, benzoic acid, glutathione, EDTA, 4-hexylresorcinol, and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase. Agaricales
10552679 The presence of 5 mM glutathione, sodium chloride, or benzoic acid caused no significant alteration of the enzyme pressure stability. unknown
10945575 Heat inactivation of Escherichia coli O157:H7 in apple cider containing malic acid, sodium benzoate, and potassium sorbate. Escherichia coli O157
10945575 E. coli O157:H7 and various amounts of potassium sorbate (0 to 0.2%), sodium benzoate (0 to 0.2%), and malic acid (0 to 1%) were added to apple cider. unknown
9434277 Ionization and solubilization of 4 alkyl benzoic acids and 4 alkyl anilines in sodium taurodeoxycholate solutions. Unknown
9434277 PURPOSE: The aqueous solubility and the extent of solubilization and ionization constant in sodium taurodeoxycholate (NaTDC) solutions of a series of benzoic acid and aniline derivatives were measured as a basis to characterize and thereby help predict the nature of the interaction of drugs with bile aggregates. unknown
10561478 On the other hand, catalase (1 U/ml), and hydroxyl radical and singlet oxygen scavengers (10 mM sodium benzoate, 300 mM mannitol, 1 mM tryptophan and 1 mM sodium azide) did not protect xanthine/xanthine oxidase-induced fluorescence quenching of DPBF-labeled liposomes. unknown
10898635 These analyses showed that all the samples presented a similar profile composed of at least eight identified phenolic compounds, several unidentified characteristic procyanidin polymers, and sodium benzoate as preservative of quince jams. Unknown
10996903 It was not inhibited by p-hydroxy benzoic acid, sorbic acid, methylpropyl p-benzoic acid and sodium nitrite in the concentration range of 0.04 to 0.5%, whereas it was inhibited by 100 ppm of butylated hydroxy anisole (BHA), 200 ppm of butylated hydroxy toluene (BHT), and 300 ppm of propyl gallate. Staphylococcus aureus
Swine
10953868 On the contrary, it appeared to be resistant to sulfhydryl reagents--4(hydroxymercury) benzoic acid, sodium salt and N-ethylmaleimide. unknown
10199339 OBJECTIVE: To determine whether hemodialysis, in conjunction with intravenous sodium phenylacetate, sodium benzoate, and arginine hydrochloride therapy, would be efficacious in a patient with hyperammonemic coma after solid-organ transplantation. Human
10199339 To our knowledge, she is the first patient with this complication after solid-organ transplantation to survive after combined therapy with sodium phenylacetate, sodium benzoate, arginine hydrochloride, and hemodialysis. unknown
10199339 CONCLUSIONS: The aggressive use of hemodialysis in conjunction with intravenous sodium phenylacetate, sodium benzoate, and arginine hydrochloride therapy may allow survival in patients after solid-organ transplantation. unknown
9434277 Ionization and solubilization of 4 alkyl benzoic acids and 4 alkyl anilines in sodium taurodeoxycholate solutions. Unknown
9434277 PURPOSE: The aqueous solubility and the extent of solubilization and ionization constant in sodium taurodeoxycholate (NaTDC) solutions of a series of benzoic acid and aniline derivatives were measured as a basis to characterize and thereby help predict the nature of the interaction of drugs with bile aggregates. unknown
10760473 Results of the radical scavenger experiments with superoxide dismutase, catalase and hydroxyl radical ((&z.rad;)OH) scavengers (sodium benzoate, mannitol and dimethylthiourea), deoxyribose degradation and ESR spectrometry suggest that the stimulation of Fe(3+)-dependent lipid peroxidation under acidic conditions is involved in generation of superoxide anion (O(2)(&z.rad;-)), hydrogen peroxide (H(2)O(2)) and (&z.rad;)OH during the reaction. unknown
10561478 On the other hand, catalase (1 U/ml), and hydroxyl radical and singlet oxygen scavengers (10 mM sodium benzoate, 300 mM mannitol, 1 mM tryptophan and 1 mM sodium azide) did not protect xanthine/xanthine oxidase-induced fluorescence quenching of DPBF-labeled liposomes. unknown
10898635 These analyses showed that all the samples presented a similar profile composed of at least eight identified phenolic compounds, several unidentified characteristic procyanidin polymers, and sodium benzoate as preservative of quince jams. Unknown
10996903 It was not inhibited by p-hydroxy benzoic acid, sorbic acid, methylpropyl p-benzoic acid and sodium nitrite in the concentration range of 0.04 to 0.5%, whereas it was inhibited by 100 ppm of butylated hydroxy anisole (BHA), 200 ppm of butylated hydroxy toluene (BHT), and 300 ppm of propyl gallate. Staphylococcus aureus
Swine
10953868 On the contrary, it appeared to be resistant to sulfhydryl reagents--4(hydroxymercury) benzoic acid, sodium salt and N-ethylmaleimide. unknown
10888553 Fresh elder flowers (Sambucus nigra L.) were extracted with an aqueous solution containing sucrose, peeled lemon slices, tartaric acid, and sodium benzoate to make elder flower syrup. Unknown
10898635 These analyses showed that all the samples presented a similar profile composed of at least eight identified phenolic compounds, several unidentified characteristic procyanidin polymers, and sodium benzoate as preservative of quince jams. Unknown
10910223 Rapid high-performance liquid chromatography method for the analysis of sodium benzoate and potassium sorbate in foods. Unknown
10910223 A rapid and reliable method is presented for the determination of the preservatives sodium benzoate and potassium sorbate in fruit juices, sodas, soy sauce, ketchup, peanut butter, cream cheese, and other foods. unknown
10910223 The HPLC determination of the preservatives was performed using a reversed-phase C18 column and UV detection at 225 nm for sodium benzoate and 255 nm potassium sorbate. unknown
10910223 The percentage of preservative in the sample was calculated by external standard using authentic sodium benzoate and potassium sorbate. unknown
10910223 Apple juice, apple sauce, soy sauce, and peanut butter, spiked at 0.10 and 0.050% for both sodium benzoate and potassium sorbate, yielded recoveries ranging from 82 to 96%. unknown
10945575 Heat inactivation of Escherichia coli O157:H7 in apple cider containing malic acid, sodium benzoate, and potassium sorbate. Unknown
10945575 E. coli O157:H7 and various amounts of potassium sorbate (0 to 0.2%), sodium benzoate (0 to 0.2%), and malic acid (0 to 1%) were added to apple cider. unknown
10923831 Four new compounds, three phenanthrene derivatives, aristolochic acid-III methyl ester (1), cepharanone C (2), and sodium 7-hydroxyl-8-methoxyaristolate (3), and the benzoate derivative, sodium 3,4-dimethoxybenzoate (4), together with 53 known compounds were isolated and characterized from the fresh root and stem of Aristolochia cucurbitifolia. Unknown
10955509 A micellar electrokinetic capillary method for the simultaneous determination of the sweeteners dulcin, aspartame, saccharin, and acesulfame-K and the preservatives sorbic acid; benzoic acid; sodium dehydroacetate; and methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutyl-p-hydroxybenzoate in preserved fruits is developed. Unknown
10953868 On the contrary, it appeared to be resistant to sulfhydryl reagents--4(hydroxymercury) benzoic acid, sodium salt and N-ethylmaleimide. unknown
10955279 When hepatocytes from rats fed a standard diet were treated with a mixture of four major food additives (sorbitol, sodium L(+)-glutamate, benzoic acid, and propylene glycol) or a mixture of six typical artificial food colors (erythrosine, allura red, new coccine, brilliant blue, tertrazine, and fast green), the in vitro treated food-color mixture itself showed cytotoxicity: the reduction of cell viability and decreases in the activities of gluconeogenesis and ureogenesis. Unknown
10966432 Calcium propionate at 3 mg ml(-1) was not effective under the same assay conditions, while sodium benzoate caused inhibition similar to L. plantarum 21B. Unknown
10960503 Effect of pantothenic acid on hippurate formation in sodium benzoate-treated HepG2 cells. Unknown
10960503 Sodium benzoate (SB) therapy has been beneficial in the treatment of hyperammonemia. unknown
10996903 It was not inhibited by p-hydroxy benzoic acid, sorbic acid, methylpropyl p-benzoic acid and sodium nitrite in the concentration range of 0.04 to 0.5%, whereas it was inhibited by 100 ppm of butylated hydroxy anisole (BHA), 200 ppm of butylated hydroxy toluene (BHT), and 300 ppm of propyl gallate. Unknown
11004581 The efficiency of MPO inhibitors to prevent LDL damage increased in the series benzohydroxamic acid < salicylhydroxamic acid < 3-amino-1,2,4-triazole < sodium azide < potassium cyanide < p-hydroxy-benzoic acid hydrazide, while for the HOCl traps the protective efficiency increased in the series glycine < taurine < methionine. unknown
10999432 The adduct production was inhibited by the addition of specific *OH scavengers such as sodium benzoate and methional to the blood. unknown
11048857 Two sample pairs were orange juice spiked with naringin, neohesperidin, sodium benzoate, and potassium sorbate. Unknown
11083500 A second viral infusion 14 days after the first dose further prolonged the life span to an average of 36.2 +/- 7.0 days, and to 40.7 +/- 3.3 days with a concurrent daily injection of arginine and sodium benzoate. unknown
11068691 When sodium benzoate was used instead of DcNa, a similar result was obtained with the addition of CVP. unknown
11133437 Using a complete factorial experimental design, the effect of pH (3. 1 to 4.3), storage temperature and time (5 to 35 degrees C for 0 to 6 h or 12 h), preservatives (0, 0.05, or 0.1% potassium sorbate or sodium benzoate), and freeze-thaw (F-T; -20 degrees C, 48 h and 4 degrees C, 4 h) treatment combinations (a total of 1,600 treatments) on the probability of achieving a 5-log(10)-unit reduction in a three-strain E. coli O157:H7 mixture in cider was determined. Unknown
11104170 Administration of sodium benzoate and sodium phenylacetate for activating alternative nitrogen waste pathway were used associated with protein restriction. unknown
11131349 The patient was treated with sodium benzoate, lactulose and a protein-restricted diet. Unknown
11151894 Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution. Unknown
11151894 OBJECTIVE: The administration of sodium benzoate provides an alternative pathway for the disposal of waste nitrogen and this substance has been used to treat patients with urea cycle defects and more recently cirrhotics with hepatic encephalopathy. unknown
11151894 These results confirm what has already been observed in experimental animals and suggest a note of caution in the use of sodium benzoate in cirrhotic patients. unknown
11152975 Nitrosation of propranolol under standard conditions recommended by the World Health Organization (10mM propranolol hydrochloridre, 40mM sodium nitrite, pH 3.5) was performed in the absence and in the presence of benzoic acid and of twelve mono-, di- and tri-hydroxybenzoic acids, added to the nitrosation mixture in concentrations ranging from 2 to 40mM, in order to examine their effect on the nitrosation reaction. Unknown
11169615 We determined that NG108-15 cells were consistently very responsive to several potent sweeteners and bitter compounds, such as sodium saccharin, guanidino- sweeteners, denatonium benzoate, quinine, and ranitidine. Unknown
11225838 Thiourea, sodium benzoic acid and isopropanol can decrease DNA damage by hydroxyl radicals, and their protection efficiencies are discussed. unknown
11252495 Raw chicken wings inoculated with a mixture of five strains of Y. lipolytica isolated from raw poultry were dipped in solutions containing 2, 5, or 8% lactic acid, 2% lactic acid containing 0.2, 0.4, or 0.8% potassium sorbate or sodium benzoate, and 4, 8, or 12% trisodium phosphate solution. Unknown
11330720 The method was tested with Ralstonia eutropha DSM 4058 growing on phenol, and Variovorax paradoxus DSM 4065 growing on sodium benzoate. unknown
11328833 METHODS: The assay measured the capacity of the biological fluids to inhibit the production of thiobarbituric acid reactive substances (TBARS) from sodium benzoate under the influence of the free oxygen radicals derived from Fenton's reaction. Unknown
11329530 A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid. unknown
11337171 The objective in the present study was to understand the relationship between the increased skin concentration of benzoate as a model drug after topical application of its sodium salt and the electric field intensity produced in the skin barrier, the stratum corneum, by electroporation. Unknown
11337171 A piece of excised abdominal hairless rat skin was set in a Franz type diffusion cell, and 0.5% sodium benzoate and physiological saline were applied to the stratum corneum and dermis sides, respectively. unknown
11347987 Six storage conditions (refrigeration [4 to 5 degrees C]; temperature abuse [6 to 10 degrees C]; room temperature [20 to 25 degrees C]; refrigerated with 0.1% sodium benzoate, 0.1% potassium sorbate, or both) were modeled. Unknown
11380566 METHODS: We used the whole-cell voltage-clamp technique in the mouse neuroblastoma cell line N1E-115 to investigate the effects of BIA 2-093 and CBZ on VGSCs, displacement of [3H]-batrachotoxinin A 20-alpha-benzoate ([3H]-BTX), and [3H]-saxitoxin to define their relative potency to bind to rat brain sodium channels, and inhibition of uptake of 22Na by rat brain cortical synaptosomes stimulated by veratridine as a measure of sodium entry. unknown
11460251 High substrate loading, high pH values, and the addition of the growth inhibitors sodium dodecylsulfate and sodium benzoate have been used in combination to alter the growth characteristics of Leuconostoc mesenteroides NRRL-B523 grown in batch conditions. Unknown
11460251 Increasing the concentration of sodium benzoate had no effect on lag time, but reduced the growth rate until the threshold concentration of 0.6%, above which bacteria did not grow. unknown
11434179 The initial therapy of this disease comprises administration of benzoate sodium, arginine, lactulose, neomycin, and restrictive alimentation based on carbohydrates. Unknown
11463262 The reactions of sodium benzoate with a series of trimesylates derived from glucosamine have been examined in an attempt to gain facile access to galactosamine analogues. unknown
11510219 Organic compounds, including humic acid, benzoic acid, and sodium dodecyl sulfate, decreased PAH degradation rate constants by scavenging oxygen derived reactive transients. unknown
11516495 Their effective charge densities were estimated from the partition coefficients of sodium benzoate (NaBA) and decreased from -0.033 to -0.044 mol dm(-3) with increasing contents of HEA. unknown
11569561 Sodium benzoate is added to Pyrodex, as a fuel and burn rate modifier. unknown
11602992 In the present work hydrolysis of methyl benzoate was carried out using aqueous sodium hydroxide solution at room temperature in the presence of ultrasound since otherwise the same reaction takes place at relatively high temperature. Unknown