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Dr. James C Fuscoe
Director, Center for Functional Genomics of Division of Systems Toxicology
Affiliation UALR NCTR
Office NCTR, 53E-119
Email jfuscoe AT nctr.fda.gov
Website http://
Phone 870-543-7126
Fax 870-543-7682
Mail 3900 NCTR Rd., HFT-130
Jefferson, Arkansas 72079
 
 
Core Areas
  • Life sciences
Research Areas
Dr. James Fuscoe has been involved in developing and utilizing biotechnology in the understanding of cancer and other diseases for more than 25 years. His studies have included some of the first publications on DNA characterization of genetic defects in mammalian cell selectable marker genes, the construction of a complete set of human chromosome-specific gene libraries for application to human diseases, development of the widely used fluorescence in situ hybridization (FISH) technique for mapping, analysis of chromosomal defects, and novel PCR methods for quantitative analysis of mutations. Most recently, he has established a microarray center at NCTR for toxicogenomics research. Dr. Fuscoe has authored or co-authored more than 65 peer-reviewed publications applying molecular genetic approaches to development and application of molecular biomarkers to detect effects of drug exposures, mammalian molecular genetics, and mutagenesis / carcinogenesis. Students working in Dr. Fuscoe’s laboratory may expect to be involved in projects related to toxicogenomics, utilizing microarray technology and functional genomic approaches to understand mechanisms of toxicity and to develop biomarkers of exposure and effect. Strong collaborations exist with the statistics and toxicoinformatics departments at NCTR and joint projects can be developed incorporating toxicology, functional genomics technology, and bioinformatics.
 
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This page was created on September 23, 2009.