.     Home Academics   Graduate program     M.S.     Ph.D.     Faculty       Ali, Nawab       Baltosser, William H       Bayrak, Coskun       Beger, Richard       Benes, Helen       Berleant, Dan       Bowyer, John F       Bruhn, Russel       Bush, John       Chan, Yupo       Chiang, Chia-Chu       Compadre, Cesar       Dagtas, Serhan       Mock, Donald       Nagarajan, Radhakris       Patterson, Tucker       Pidugu, Srikanth B       Pierce, Elizabeth M       Preissl, Hubert T       Ramaswamy, Srinivasa       Reis, Robert J S       Seker, Remzi       Simpson, Pippa       Slikker, William       Soulsby, Sr., Michae       Suva, Larry       Tang, Peiyi       Thompson, Gary A       Tong, Weida       Tudoreanu, M Eduard       Vanbiervliet, Alan G       Wigand, Rolf T       Xu, Xiaowei       Zhang, Jianjun       Zhou, Yi-Hong       Darsey, Jerry A       Elsalloukh, Hassan       Epstein, Joshua       Eswaran, Hari       Fuscoe, James C       Gealt, Michael A       Govindan, Rathinaswa       Gray, Wayne L       He, Qingfang       Iqbal, Kamran       Jennings, Steven F       Jo, Chan-Hee       Kane, Cynthia (Cindy       Kaufmann, Eric R       Kieber-Emmons, Thoma       Light, Kim       Liu, Xian       Lowery, Curtis L       Luba, James       Ma, Xiaodong       Milanova, Mariofanna       Ounpraseuth, Songthi     FAQ   Undergraduate minor   Courses   Certificates   Admission Research Events Resources Contacts Jobs Calendar   . Dr. John F. Bowyer Research Pharmacologist Affiliation Division of Neurotoxicology, NCTR Office HFT-132 Email john.bowyer AT fda.hhs.gov Website http://www.fda.gov/nctr/staff/bios-html/jbowyer.html Phone 870-543-7194 Fax 870-543-7745 Mail National Center for Toxicological Research 3900 NCTR Drive Jefferson, AR 72079-9502     Core Areas Molecular Neurobiology Molecular Neurotoxicology Research Areas I have been active in research related to the neurotoxicology of substituted amphetamines (amphetamine, methamphetamine, ecstasy, e.g.) and the role of catecholaminergic systems in neurotoxicity for over 20 years. This research has helped contributed to the further understanding of dopaminergic systems in the brain and how they are involved in neurotoxic insults. More, recent studies have focused on the characterization of the various aspects of the neurotoxicity produced by substituted amphetamines, which have previously been unknown or ignored by applying the techniques of immunohistochemistry, neurochemistry and gene expression to understand the mechanisms behind these neurotoxicities. As particularly related to Bioinformatics, my recent studies have applied the techniques of cDNA array technology (molecular biology) to determine how neurotoxic insults alter gene expression to find relevant biomarkers of neurotoxic insult and mechanisms involved in repair and adaptation to damage. The gene expression data generated by cDNA arrays is vast and amenable to bioinformatics processing. Ongoing research involves the use of cDNA arrays to determine changes in gene expression that are related to regeneration of damaged terminals in the basal ganglia of rat brain. As well, research is planned to look at the overall gene expression changes resulting in a genetically mutant mouse deficient for the enzyme necessary for arylformamidase which is important in brain and immune function.   .   . Site map | Privacy policy | Webmaster | AR BRIN Copyright © 2004-2008 Donaghey College of Information Science and Systems Engineering Created and maintained by MidSouth Bioinformatics Center   This page was created on June 3, 2008.